Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with this Quarterly Report on Form 10-Q for the period ending June 30, 2026 of ImageneBio, Inc. (the “Company”) as filed with the Securities and Exchange Commission on the date hereof (the “Report”), each of the undersigned hereby certifies, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of her knowledge:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: August 5, 2026		By:	/s/ Kristin Yarema
			Kristin Yarema, Ph.D.
			Chief Executive Officer (Principal Executive Officer)

Date: August 5, 2026		By:	/s/ Yanina Grant-Huerta
			Yanina Grant-Huerta
			Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer)