v3.23.1
Share-Based Compensation - Summary of Stock Option Activity (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2023
Dec. 31, 2022
Stock Option Shares    
Shares, Outstanding at beginning balance (in shares) 2,990,423  
Shares, Granted (in shares) 1,261,506  
Shares, Exercised (in shares) (1,983)  
Shares, Expired/cancelled (in shares) (403,581)  
Shares, Outstanding at ending balance (in shares) 3,846,365 2,990,423
Shares, Options exercisable (in shares) 851,373  
Shares, Vested and expected (in shares) 3,846,365  
Weighted Average Exercise Price    
Weighted Average Exercise Price, Outstanding at beginning balance (in dollars per share) $ 19.28  
Weighted Average Exercise Price, Granted (in dollars per share) 9.60  
Weighted Average Exercise Price, Exercised (in dollars per share) 4.45  
Weighted Average Exercise Price, Expired/cancelled (in dollars per share) 20.20  
Weighted Average Exercise Price, Outstanding at ending balance (in dollars per share) 16.51 $ 19.28
Weighted Average Exercise Price, Options exercisable (in dollars per share) 18.56  
Weighted Average Exercise Price, Vested and expected to vest (in dollars per share) $ 16.51  
Weighted Average Remaining Contractual Term, Outstanding 8 years 8 months 23 days 8 years 7 months 2 days
Weighted Average Remaining Contractual Term, Options exercisable 6 years 9 months 21 days  
Weighted Average Remaining Contractual Term, Vested and expected to vest 8 years 8 months 23 days  
Aggregate Intrinsic Value, Outstanding $ 1,259 $ 2,849
Aggregate Intrinsic Value, Options exercisable 1,127  
Aggregate Intrinsic Value, Vested and expected to vest $ 1,259