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Employee Stock Purchase Plan | 6 Months Ended
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Jun. 30, 2026
Share-Based Payment Arrangement [Abstract] |
Employee Stock Purchase Plan | 10. Employee Stock Purchase Plan On August 17, 2021, a special meeting of the Company’s stockholders was held to approve the Reverse Merger and related matters, at which the Company's stockholders considered and approved the Company’s 2021 ESPP which permits participants to contribute up to 15% of their eligible compensation during defined rolling six-month offering periods to purchase the Company's common stock. The purchase price of the shares will be 85% of the lower of the fair market value of the Company's common stock on the first day of trading of the offering period or on the applicable purchase date. Upon approval of the 2021 ESPP by the stockholders, Aerpio’s Amended and Restated 2017 Employee Stock Purchase Plan terminated. An aggregate of 519,563 shares of common stock was initially reserved for issuance under the 2021 ESPP. The number of shares of common stock available for issuance under the 2021 ESPP is automatically increased on the first day of each fiscal year beginning with the 2022 fiscal year in an amount equal to the least of: • 310,617 shares of common stock; • one percent (1%) of the outstanding shares of all classes of common stock on the last day of the immediately preceding fiscal year; or • an amount to be determined by the board of directors or its designated committee no later than the last day of the immediately preceding fiscal year. Under this mechanism, a total of 310,617 and 246,807 shares of common stock were added to the 2021 ESPP on January 1, 2026 and 2025, respectively. Shares of common stock issuable under the 2021 ESPP will be authorized, but unissued, or reacquired shares of common stock. If the Company’s capital structure changes because of a stock dividend, stock split or similar event, the number of shares that can be issued under the 2021 ESPP will be appropriately adjusted. The Company opened enrollment into the 2021 ESPP in May 2022. The Company uses the Black-Scholes model to determine the estimated fair value for purchases under the 2021 ESPP. Black-Scholes models require the input of various assumptions, including the expected life, expected dividend yield, price volatility and risk-free interest rate of the underlying stock. The expected volatility used in calculating the estimated fair value for purchases under the 2021 ESPP is based on the historical volatility of the Company's common stock. The calculation was based on the following assumptions:
|  | Three and Six Months Ended June 30, 2026 |  |  | Three and Six Months Ended June 30, 2025 |
Strike price (per share) |  | $1.82 - $4.00 |  |  | $1.69 - $2.11 |
Risk-free interest rate |  | 3.77% - 3.80% |  |  | 4.29% - 4.44% |
Expected volatility |  | 73.73% - 80.01% |  |  | 55.26% - 88.23% |
Expected term (in years) |  |  | 0.5 |  |  |  | 0.5 |
Expected dividend yield |  |  | — |  |  |  | — |
As of June 30, 2026, and December 31, 2025, 1,318,718 and 1,023,856 shares of common stock were available for issuance under the 2021 ESPP, respectively. The Company had an outstanding liability of $42.0 thousand and $24.0 thousand as of June 30, 2026, and December 31, 2025, respectively, which will be recognized over six months. For the six months ended June 30, 2026 and 2025, 15,755 and 16,337 shares were issued under the 2021 ESPP, respectively.

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