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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $)
 12 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Product revenues:      
Related party $ 0 $ 590,000 $ 591,000
Third party 7,983,000 7,664,000 5,246,000
Total product revenues 7,983,000 8,254,000 5,837,000
Cost of product revenues 3,837,000 3,908,000 3,394,000
Gross profit 4,146,000 4,346,000 2,443,000
Development revenues:      
Development, related party 1,992,000 2,122,000 8,840,000
Research grants and other 21,000 251,000 53,000
Total development revenues 2,013,000 2,373,000 8,893,000
Operating expenses:      
Research and development 10,904,000 9,687,000 12,231,000
Sales and marketing 13,560,000 11,040,000 6,583,000
General and administrative 14,727,000 12,570,000 10,415,000
Change in fair value of warrants (4,360,000) (1,285,000) 4,574,000
Change in fair value of option liability 740,000 30,000 (920,000)
Total operating expenses 35,571,000 32,042,000 32,883,000
Operating loss (29,412,000) (25,323,000) (21,547,000)
Other income (expense):      
Interest income 9,000 9,000 20,000
Interest expense (2,784,000) (2,052,000) (1,427,000)
Other income (expense), net (55,000) 23,000 (218,000)
Equity loss from investment in joint venture (209,000) (151,000) (44,000)
Total other income (expense) (3,039,000) (2,171,000) (1,669,000)
Net loss $ (32,451,000) $ (27,494,000) $ (23,216,000)
Basic and diluted net loss per common share (in dollars per share) $ (0.61) $ (0.60) $ (0.65)
Basic and diluted weighted average common shares (in shares) 53,504,030 45,947,966 35,939,260