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Stockholders' Equity (Details) (USD $) | 0 Months Ended | 1 Months Ended | 12 Months Ended | 13 Months Ended |  |  |  | 0 Months Ended | 1 Months Ended | 12 Months Ended | 0 Months Ended | 1 Months Ended | 12 Months Ended |
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Dec. 13, 2010 | May 14, 2009 | Dec. 31, 2012 | Dec. 31, 2010 | Oct. 31, 2010 | May 31, 2009 | Mar. 31, 2009 | Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010 | Jun. 30, 2010 | Jun. 30, 2010 | Jun. 19, 2009 | Mar. 10, 2009 | Dec. 31, 2004 | Dec. 13, 2010 Astellas Pharma Inc. [Member] | Apr. 09, 2012 Seaside 88, LP [Member] | Jul. 11, 2011 Seaside 88, LP [Member] | Jun. 19, 2009 Seaside 88, LP [Member] | Dec. 31, 2012 Seaside 88, LP [Member] | Jul. 11, 2011 Seaside 88, LP [Member] Initial Closing Period [Member] | Jul. 11, 2011 Seaside 88, LP [Member] Every Two Weeks [Member] | Jul. 11, 2011 Seaside 88, LP [Member] Ten Day Trading Period [Member] | Dec. 19, 2012 Lazard Capital Markets, LLC [Member] | Dec. 31, 2012 Lazard Capital Markets, LLC [Member] | Dec. 31, 2012 Warrants issued August 2008 [Member]
Preferred Stock [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, shares authorized (in shares) |  |  | 5,000,000 |  |  |  |  | 5,000,000 | 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, par value (in dollars per share) |  |  | $ 0.001 |  |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, shares outstanding (in shares) |  |  | 0 |  |  |  |  | 0 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from private placement of stock |  | $ 4,252,000 |  |  | $ 20,700,000 |  | $ 10,000,000 |  |  |  | $ 17,314,000 |  |  |  |  | $ 10,000,000 |  | $ 6,000,000 |  | $ 30,172,000 |  |  |  | $ 20,007,000 | $ 3,001,000 |
Common stock issued (in shares) |  | 1,864,783 | 7,020,000 | 1,428,571 | 4,600,000 | 1,864,783 | 4,771,174 |  |  |  | 3,300,000 | 7,150,000 |  |  |  | 1,428,571 | 5,826,262 | 1,326,262 | 275,000 |  |  |  |  | 1,053,000 | 7,020,000 |
Additional shares of common stock, conversion |  | one (1) share and one and three-fourths (1.75) warrants |  |  |  |  | one (1) share and one and four-tenths (1.4) warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period for warrants exercisable after date of issuance |  |  |  |  |  |  | 6 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expire period after date of first exercisable |  | 5 years |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional shares of common stock (in shares) |  | 3,263,380 |  |  |  | 3,263,380 | 6,679,644 |  |  |  |  |  | 7,150,000 | 6,679,644 |  |  |  |  |  |  |  |  |  |  | 1,053,000 | 2,129,309
Common stock at a purchase price (in dollars per unit) |  | $ 2.28 |  |  | $ 4.50 |  |  |  |  |  |  |  |  | $ 2.10 |  |  |  |  |  |  |  |  |  |  | $ 2.85 |
Sale of stock, price per share (in dollars per share) |  |  |  |  | $ 4.23 |  |  |  |  |  |  |  |  |  |  | $ 7.00 |  | $ 4.52 |  |  |  |  |  |  | $ 2.69 |
Deferred revenues |  |  | 2,635,000 |  |  |  |  | 2,635,000 | 5,244,000 |  |  |  |  |  | 1,500,000 | 2,526,000 |  |  |  |  |  |  |  |  |  |
Expected expiration period for recognition of deferred amount | 2 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued (in shares) |  |  | 65,914,050 |  |  |  |  | 65,914,050 | 56,594,683 |  |  |  |  |  |  |  | 5,826,262 | 6,326,262 |  |  | 1,326,262 | 250,000 |  |  |  |
Purchase period of common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 30 days | 14 days |  |  |  |
Number of closings |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20 |  |  |  |  |  |  |  |
Offering price per share (in dollars per share) |  |  |  |  | $ 4.23 |  |  |  |  |  |  |  |  |  |  | $ 7.00 |  | $ 4.52 |  |  |  |  |  |  | $ 2.69 |
Purchase price of common stock, percent (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 88.00% |  |  |  |  | 90.25% |  |  |
Trading period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 days |  |  |  |  |  |  |  |
Proceeds from sale of common stock |  |  |  |  |  |  |  | $ 24,953,000 | $ 13,286,000 | $ 45,486,000 |  |  |  |  |  |  | $ 18,233,000 | $ 6,000,000 |  |  |  |  |  |  |  |
Warrant Adjustments [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued (in shares) |  | 1,864,783 | 7,020,000 | 1,428,571 | 4,600,000 | 1,864,783 | 4,771,174 |  |  |  | 3,300,000 | 7,150,000 |  |  |  | 1,428,571 | 5,826,262 | 1,326,262 | 275,000 |  |  |  |  | 1,053,000 | 7,020,000 |
Warrants issued to purchase shares of common stock (in shares) |  | 3,263,380 |  |  |  | 3,263,380 | 6,679,644 |  |  |  |  |  | 7,150,000 | 6,679,644 |  |  |  |  |  |  |  |  |  |  | 1,053,000 | 2,129,309
Warrant exercise price (in dollars per share) |  |  | $ 25.00 |  |  | $ 2.62 | $ 2.59 | $ 25.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5.44

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