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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $)
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Product revenues:      
Related party $ 0 $ 0 $ 590,000
Third party 8,709,000 7,983,000 7,664,000
Total product revenues 8,709,000 7,983,000 8,254,000
Cost of product revenues 4,000,000 3,837,000 3,908,000
Gross profit 4,709,000 4,146,000 4,346,000
Development revenues:      
Development, related party 2,882,000 1,992,000 2,122,000
Development 2,529,000 0 0
Government contracts and other 381,000 21,000 251,000
Total development revenues 5,792,000 2,013,000 2,373,000
Operating expenses:      
Research and development 13,628,000 10,904,000 9,687,000
Sales and marketing 9,488,000 13,560,000 11,040,000
General and administrative 15,672,000 14,727,000 12,570,000
Change in fair value of warrants (209,000) (4,360,000) (1,285,000)
Change in fair value of option liability 340,000 740,000 30,000
Total operating expenses 38,919,000 35,571,000 32,042,000
Operating income (loss) (28,418,000) (29,412,000) (25,323,000)
Other income (expense):      
Interest income 4,000 9,000 9,000
Interest expense (3,386,000) (2,784,000) (2,052,000)
Other income (expense), net (314,000) (55,000) 23,000
Equity loss from investment in joint venture (165,000) (209,000) (151,000)
Total other income (expense) (3,861,000) (3,039,000) (2,171,000)
Net loss $ (32,279,000) $ (32,451,000) $ (27,494,000)
Basic and diluted net loss per common share (in dollars per share) $ (0.55) $ (0.61) $ (0.6)
Basic and diluted weighted average common shares (in shares) 58,679,687 53,504,030 45,947,966