Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.

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Commitments and Contingencies (Details) (USD $)	12 Months Ended
Commitments and Contingencies (Details) (USD $)	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Operating Leases [Abstract]
2013	$ 1,931,000
2014	1,752,000
2015	1,823,000
2016	1,870,000
2017	1,591,000
Operating Leases, Total	8,967,000
Rent expense	2,980,000	2,524,000	2,186,000
Clinical Research Study Obligations [Member]
Recorded Unconditional Purchase Obligation [Line Items]
Purchase obligation, due in next twelve months	150,000
Purchase obligation	11,700,000
Pre Clinical Research Study Obligations [Member]
Recorded Unconditional Purchase Obligation [Line Items]
Purchase obligation, due in next twelve months	23,000
Minimum Purchase Obligation, Supply Agreement [Member]
Recorded Unconditional Purchase Obligation [Line Items]
Minimum purchase obligations, total	1,743,000
Minimum purchase obligations due within one year	$ 1,743,000