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Income Taxes (Details) (USD $)
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Reconciliation of the total income tax provision tax rate [Abstract]      
Income tax expense (benefit) at federal statutory rate (in hundredths) (34.00%) (34.00%) (34.00%)
Income tax expense (benefit) at state statutory rate (in hundredths) (2.79%) (3.36%) (2.62%)
Mark to market permanent adjustment (in hundredths) (0.24%) (5.02%) (1.71%)
Change in federal valuation allowance (in hundredths) 35.86% 45.72% 40.47%
Change in State Rate (in hundredths) (8.36%) (3.29%) 0.00%
Deferred revenue (in hundredths) 0.00% (2.09%) (2.82%)
Foreign rate differential (in hundredths) (0.04%) 0.00% 0.00%
Other, net (in hundredths) 9.57% 2.04% 0.68%
Total income tax provision (in hundredths) 0.00% 0.00% 0.00%
Deferred tax assets [Abstract]      
Allowances and reserves $ 169,000 $ 292,000  
Accrued expenses 1,053,000 587,000  
Deferred revenue 1,138,000 3,276,000  
Stock based compensation 5,635,000 4,886,000  
Net operating loss carryforwards 87,045,000 73,774,000  
Income tax credit carryforwards 5,729,000 5,569,000  
Property and equipment, principally due to differences in depreciation 422,000 707,000  
Other 295,000 181,000  
Deferred tax assets (Total) 101,486,000 89,272,000  
Valuation allowance (101,476,000) (89,200,000)  
Total deferred tax assets, net of allowance 10,000 72,000  
Deferred tax liabilities [Abstract]      
Intangibles (10,000) (72,000)  
Total deferred tax liability (10,000) (72,000)  
Net deferred tax assets (liability) 0 0  
Schedule of reconciliation of unrecognized tax benefits activity [Roll Forward]      
Unrecognized Tax Benefits - Beginning 1,304,000 1,166,000 1,115,000
Gross increases - tax positions in prior period 0 0 0
Gross decreases - tax positions in prior period 0 0 (49,000)
Gross increase - current-period tax positions 90,000 138,000 100,000
Settlements 0 0 0
Lapse of statute of limitations 0 0 0
Unrecognized Tax Benefits - Ending 1,394,000 1,304,000 1,166,000
Income Tax Contingency [Line Items]      
Increased valuation allowance 12,276,000    
Net operating loss carryforwards, Expire date expire in 2019 and 2013    
Federal tax carry forward 4,096,000    
State tax credit carryforwards 4,244,000    
Cumulative change in ownership (in hundredths) 50.00%    
Period of net operating loss and R&D tax credit carry forwards to offset future taxable income 3 years    
Excess tax benefits 1,169,000    
Period for material changes of liability for uncertain tax benefits 12 months    
Japan [Member]
      
Income Tax Contingency [Line Items]      
Foreign tax loss carryforward 11,730,000    
Switzerland [Member]
      
Income Tax Contingency [Line Items]      
Foreign tax loss carryforward 1,632,000    
India [Member]
      
Income Tax Contingency [Line Items]      
Foreign tax loss carryforward 78,000    
Federal [Member]
      
Income Tax Contingency [Line Items]      
Tax loss carryforwards 222,237,000    
California [Member]
      
Income Tax Contingency [Line Items]      
Tax loss carryforwards 137,500,000    
Massachusetts [Member]
      
Income Tax Contingency [Line Items]      
Tax loss carryforwards 671,000    
Stock Option [Member]
      
Income Tax Contingency [Line Items]      
Increased valuation allowance $ 579,000