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Stockholders' Equity (Details) (USD $)
 0 Months Ended 1 Months Ended 12 Months Ended 13 Months Ended 0 Months Ended 1 Months Ended 12 Months Ended 0 Months Ended 1 Months Ended 12 Months Ended
Dec. 13, 2010
May 14, 2009
Dec. 31, 2012
Dec. 31, 2010
Oct. 31, 2010
May 31, 2009
Mar. 31, 2009
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Jun. 30, 2010
Jun. 30, 2010
Jun. 19, 2009
Mar. 10, 2009
Dec. 31, 2004
Dec. 13, 2010
Astellas Pharma Inc. [Member]
Apr. 09, 2012
Seaside 88, LP [Member]
Jul. 11, 2011
Seaside 88, LP [Member]
Jun. 19, 2009
Seaside 88, LP [Member]
Dec. 31, 2012
Seaside 88, LP [Member]
Jul. 11, 2011
Seaside 88, LP [Member]
Initial Closing Period [Member]
Jul. 11, 2011
Seaside 88, LP [Member]
Every Two Weeks [Member]
Jul. 11, 2011
Seaside 88, LP [Member]
Ten Day Trading Period [Member]
Dec. 19, 2012
Lazard Capital Markets, LLC [Member]
Dec. 31, 2012
Lazard Capital Markets, LLC [Member]
Dec. 31, 2012
Warrants issued August 2008 [Member]
Preferred Stock [Abstract]                                                    
Preferred stock, shares authorized (in shares)     5,000,000         5,000,000 5,000,000                                  
Preferred stock, par value (in dollars per share)     $ 0.001         $ 0.001 $ 0.001                                  
Preferred stock, shares outstanding (in shares)     0         0 0                                  
Common Stock [Abstract]                                                    
Proceeds from private placement of stock   $ 4,252,000     $ 20,700,000   $ 10,000,000       $ 17,314,000         $ 10,000,000   $ 6,000,000   $ 30,172,000       $ 20,007,000 $ 3,001,000  
Common stock issued (in shares)   1,864,783 7,020,000 1,428,571 4,600,000 1,864,783 4,771,174       3,300,000 7,150,000       1,428,571 5,826,262 1,326,262 275,000         1,053,000 7,020,000  
Additional shares of common stock, conversion   one (1) share and one and three-fourths (1.75) warrants         one (1) share and one and four-tenths (1.4) warrants                                      
Period for warrants exercisable after date of issuance             6 months                                      
Warrants expire period after date of first exercisable   5 years         5 years                                      
Additional shares of common stock (in shares)   3,263,380       3,263,380 6,679,644           7,150,000 6,679,644                     1,053,000 2,129,309
Common stock at a purchase price (in dollars per unit)   $ 2.28     $ 4.50                 $ 2.10                     $ 2.85  
Sale of stock, price per share (in dollars per share)         $ 4.23                     $ 7.00   $ 4.52             $ 2.69  
Deferred revenues     2,635,000         2,635,000 5,244,000           1,500,000 2,526,000                    
Expected expiration period for recognition of deferred amount 2 years                                                  
Common stock, shares issued (in shares)     65,914,050         65,914,050 56,594,683               5,826,262 6,326,262     1,326,262 250,000        
Purchase period of common stock                                         30 days 14 days        
Number of closings                                   20                
Offering price per share (in dollars per share)         $ 4.23                     $ 7.00   $ 4.52             $ 2.69  
Purchase price of common stock, percent (in hundredths)                                   88.00%         90.25%      
Trading period                                   10 days                
Proceeds from sale of common stock               $ 24,953,000 $ 13,286,000 $ 45,486,000             $ 18,233,000 $ 6,000,000                
Warrant Adjustments [Abstract]                                                    
Common stock issued (in shares)   1,864,783 7,020,000 1,428,571 4,600,000 1,864,783 4,771,174       3,300,000 7,150,000       1,428,571 5,826,262 1,326,262 275,000         1,053,000 7,020,000  
Warrants issued to purchase shares of common stock (in shares)   3,263,380       3,263,380 6,679,644           7,150,000 6,679,644                     1,053,000 2,129,309
Warrant exercise price (in dollars per share)     $ 25.00     $ 2.62 $ 2.59 $ 25.00                                   $ 5.44