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Quarterly Information (unaudited) (Details) (USD $)
 3 Months Ended 12 Months Ended
Dec. 31, 2012
Sep. 30, 2012
Jun. 30, 2012
Mar. 31, 2012
Dec. 31, 2011
Sep. 30, 2011
Jun. 30, 2011
Mar. 31, 2011
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Quarterly Information (unaudited) [Abstract]                      
Product revenues $ 3,967,000 $ 1,314,000 $ 1,947,000 $ 1,481,000 $ 2,076,000 $ 2,134,000 $ 2,411,000 $ 1,362,000 $ 8,709,000 $ 7,983,000 $ 8,254,000
Gross profit 2,555,000 611,000 915,000 628,000 1,132,000 1,192,000 1,302,000 520,000 4,709,000 4,146,000 4,346,000
Development revenues 3,358,000 2,000 2,429,000 3,000 762,000 5,000 11,000 1,235,000 5,792,000 2,013,000 2,373,000
Operating expenses 8,674,000 10,945,000 10,304,000 8,996,000 7,868,000 9,020,000 5,685,000 12,998,000 38,919,000 35,571,000 32,042,000
Other income (expense) (1,062,000) (916,000) (923,000) (960,000) (932,000) (512,000) (766,000) (829,000) (3,861,000) (3,039,000) (2,171,000)
Net loss $ (3,823,000) $ (11,248,000) $ (7,883,000) $ (9,325,000) $ (6,906,000) $ (8,335,000) $ (5,138,000) $ (12,072,000) $ (32,279,000) $ (32,451,000) $ (27,494,000)
Basic and diluted net loss per share (in dollars per share) $ (0.06) $ (0.19) $ (0.13) $ (0.16) $ (0.13) $ (0.15) $ (0.1) $ (0.23) $ (0.55) $ (0.61) $ (0.6)