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Quarterly Information (unaudited) (Details) (USD $) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2013 | Sep. 30, 2013 | Jun. 30, 2013 | Mar. 31, 2013 | Dec. 31, 2012 | Sep. 30, 2012 | Jun. 30, 2012 | Mar. 31, 2012 | Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Quarterly Information (unaudited) [Abstract] |  |  |  |  |  |  |  |  |  |  |
Product revenues | $ 2,706,000 | $ 1,616,000 | $ 1,408,000 | $ 1,392,000 | $ 3,967,000 | $ 1,314,000 | $ 1,947,000 | $ 1,481,000 | $ 7,122,000 | $ 8,709,000 | $ 7,983,000
Gross profit | 1,580,000 | 685,000 | 800,000 | 636,000 | 2,555,000 | 611,000 | 915,000 | 628,000 | 3,701,000 | 4,709,000 | 4,146,000
Development revenues | 754,000 | 1,095,000 | 859,000 | 2,366,000 | 3,358,000 | 2,000 | 2,429,000 | 3,000 | 5,074,000 | 5,792,000 | 2,013,000
Operating expenses | 11,452,000 | 10,241,000 | 8,022,000 | 9,739,000 | 8,674,000 | 10,945,000 | 10,304,000 | 8,996,000 | 39,454,000 | 38,919,000 | 35,571,000
Other income (expense) | (923,000) | 3,203,000 | 3,152,000 | (930,000) | (1,062,000) | (916,000) | (923,000) | (960,000) | 4,502,000 | (3,861,000) | (3,039,000)
Net loss | $ (10,041,000) | $ (5,258,000) | $ (3,211,000) | $ (7,667,000) | $ (3,823,000) | $ (11,248,000) | $ (7,883,000) | $ (9,325,000) | $ (26,177,000) | $ (32,279,000) | $ (32,451,000)
Basic and diluted net loss per share (in dollars per share) | $ (0.14) | $ (0.08) | $ (0.05) | $ (0.11) | $ (0.06) | $ (0.19) | $ (0.13) | $ (0.16) | $ (0.39) | $ (0.55) | $ (0.61)

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- Definition Aggregate revenue earned during the period from recognition of related party deferred revenue, non-product related activities and revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements. + References No definition available. + Details
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