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Commitments and Contingencies (Details) (USD $)	12 Months Ended
Commitments and Contingencies (Details) (USD $)	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Operating Leases [Abstract]
2014	$ 2,071,000
2015	1,845,000
2016	1,892,000
2017	1,609,000
Operating Leases, Total	7,417,000
Rent expense	3,458,000	2,980,000	2,524,000
Recorded Unconditional Purchase Obligation [Line Items]
Purchase obligation, due in next twelve months	4,691,000	0
Clinical Research Study Obligations [Member]
Recorded Unconditional Purchase Obligation [Line Items]
Purchase obligation, due in next twelve months	3,530,000
Purchase obligation	4,705,000
Pre Clinical Research Study Obligations [Member]
Recorded Unconditional Purchase Obligation [Line Items]
Purchase obligation, due in next twelve months	23,000
Minimum Purchase Obligation, Supply Agreement [Member]
Recorded Unconditional Purchase Obligation [Line Items]
Minimum purchase obligations, total	850,000
Minimum purchase obligations due within one year	$ 850,000