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Income Taxes (Details) (USD $)
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Reconciliation of the total income tax provision tax rate [Abstract]      
Income tax expense (benefit) at federal statutory rate (in hundredths) (34.00%) (34.00%) (34.00%)
Income tax expense (benefit) at state statutory rate (in hundredths) (3.54%) (2.79%) (3.36%)
Gain on previously held equity interest in Joint Venture (in hundredths) (7.02%) 0.00% 0.00%
Mark to market permanent adjustment (in hundredths) (2.15%) (0.24%) (5.02%)
Change in federal valuation allowance (in hundredths) 80.13% 35.86% 45.72%
Change in State Rate (in hundredths) (1.01%) (8.36%) (3.29%)
Deferred revenue (in hundredths) 0.00% 0.00% (2.09%)
Acquired NOL's Intangibles from Joint Venture (in hundredths) (33.40%) 0.00% 0.00%
Foreign rate differential (in hundredths) 2.48% (0.04%) 0.00%
Other, net (in hundredths) (1.49%) 9.57% 2.04%
Total income tax provision (in hundredths) 0.00% 0.00% 0.00%
Deferred tax assets [Abstract]      
Allowances and reserves $ 639,000 $ 169,000  
Accrued expenses 718,000 1,053,000  
Deferred revenue 79,000 1,138,000  
Stock based compensation 6,962,000 5,635,000  
Net operating loss carryforwards 107,846,000 87,045,000  
Income tax credit carryforwards 6,710,000 5,729,000  
Property and equipment, principally due to differences in depreciation 804,000 422,000  
Other 296,000 295,000  
Deferred tax assets (Total) 124,054,000 101,486,000  
Valuation allowance (122,450,000) (101,476,000)  
Total deferred tax assets, net of allowance 1,604,000 10,000  
Deferred tax liabilities [Abstract]      
Intangibles (1,604,000) (10,000)  
Total deferred tax liability (1,604,000) (10,000)  
Net deferred tax assets (liability) 0 0  
Schedule of reconciliation of unrecognized tax benefits activity [Roll Forward]      
Unrecognized Tax Benefits - Beginning 1,394,000 1,304,000 1,166,000
Gross increases - tax positions in prior period 69,000 0 0
Gross decreases - tax positions in prior period 0 0 0
Gross increase - current-period tax positions 260,000 90,000 138,000
Settlements 0 0 0
Lapse of statute of limitations 0 0 0
Unrecognized Tax Benefits - Ending 1,723,000 1,394,000 1,304,000
Income Tax Contingency [Line Items]      
Increased valuation allowance 20,974,000    
Net operating loss carryforwards, Expire date Begin to expire in 2019 and 2013    
State tax credit carryforwards 4,015,837    
Cumulative change in ownership (in hundredths) 50.00%    
Period of net operating loss and R&D tax credit carry forwards to offset future taxable income 3 years    
Excess tax benefits 1,261,000    
Period for material changes of liability for uncertain tax benefits 12 months    
Japan [Member]
      
Income Tax Contingency [Line Items]      
Foreign tax loss carryforward 987,000    
Switzerland [Member]
      
Income Tax Contingency [Line Items]      
Foreign tax loss carryforward 1,234,000    
India [Member]
      
Income Tax Contingency [Line Items]      
Foreign tax loss carryforward 98,000    
Federal [Member]
      
Income Tax Contingency [Line Items]      
Tax loss carryforwards 249,748,000    
Federal tax carry forward 4,059,910    
Federal tax credit carryforward, Expiration date Begin to expire in 2018    
California [Member]
      
Income Tax Contingency [Line Items]      
Tax loss carryforwards 180,510,359    
Massachusetts [Member]
      
Income Tax Contingency [Line Items]      
Tax loss carryforwards 576,000    
Stock Option [Member]
      
Income Tax Contingency [Line Items]      
Increased valuation allowance $ 579,000