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Quarterly Information (unaudited) (Details) (USD $)
 3 Months Ended 12 Months Ended
Dec. 31, 2013
Sep. 30, 2013
Jun. 30, 2013
Mar. 31, 2013
Dec. 31, 2012
Sep. 30, 2012
Jun. 30, 2012
Mar. 31, 2012
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Quarterly Information (unaudited) [Abstract]                      
Product revenues $ 2,706,000 $ 1,616,000 $ 1,408,000 $ 1,392,000 $ 3,967,000 $ 1,314,000 $ 1,947,000 $ 1,481,000 $ 7,122,000 $ 8,709,000 $ 7,983,000
Gross profit 1,580,000 685,000 800,000 636,000 2,555,000 611,000 915,000 628,000 3,701,000 4,709,000 4,146,000
Development revenues 754,000 1,095,000 859,000 2,366,000 3,358,000 2,000 2,429,000 3,000 5,074,000 5,792,000 2,013,000
Operating expenses 11,452,000 10,241,000 8,022,000 9,739,000 8,674,000 10,945,000 10,304,000 8,996,000 39,454,000 38,919,000 35,571,000
Other income (expense) (923,000) 3,203,000 3,152,000 (930,000) (1,062,000) (916,000) (923,000) (960,000) 4,502,000 (3,861,000) (3,039,000)
Net loss $ (10,041,000) $ (5,258,000) $ (3,211,000) $ (7,667,000) $ (3,823,000) $ (11,248,000) $ (7,883,000) $ (9,325,000) $ (26,177,000) $ (32,279,000) $ (32,451,000)
Basic and diluted net loss per share (in dollars per share) $ (0.14) $ (0.08) $ (0.05) $ (0.11) $ (0.06) $ (0.19) $ (0.13) $ (0.16) $ (0.39) $ (0.55) $ (0.61)