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Commitments and Contingencies (Details) - USD ($)
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating Leases [Abstract]      
2016 $ 2,240,000    
2017 1,789,000    
2018 53,000    
2019 27,000    
Operating Leases, Total 4,109,000    
Obligations of Minimum Purchase Agreement [Abstract]      
2016 1,069,000    
2017 1,074,000    
2018 1,074,000    
2019 1,473,000    
2020 1,473,000    
Total 6,163,000    
Rent expense 2,455,000 $ 3,332,000 $ 3,458,000
Recorded Unconditional Purchase Obligation [Line Items]      
Purchase obligation, due in next twelve months 1,069,000    
Purchase obligation 6,163,000    
Clinical Research Study Obligations [Member]      
Obligations of Minimum Purchase Agreement [Abstract]      
2016 6,243,000    
Total 6,739,000    
Recorded Unconditional Purchase Obligation [Line Items]      
Purchase obligation, due in next twelve months 6,243,000    
Purchase obligation $ 6,739,000