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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Convertible Preferred Stock [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Deficit [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Total
Balance at (in shares) at Dec. 31, 2012   65,914,050        
Balance at at Dec. 31, 2012   $ 66,000 $ 281,117,000 $ (274,728,000) $ 0 $ 6,455,000
Stock-based compensation expense   0 3,608,000 0 0 3,608,000
Issuance of common stock under stock option plan and employee stock purchase plan   $ 0 225,000 0 0 225,000
Issuance of common stock under stock option plan and employee stock purchase plan (in shares)   338,325        
Sale of common stock, net   $ 5,000 17,811,000 0 0 17,816,000
Sale of common stock, net (in shares)   5,053,000        
Allocation of fair value for debt-related warrants   $ 0 949,000 0 0 949,000
Accumulated other comprehensive income (loss)   0 0 0 256,000 256,000
Net loss for the year ended   $ 0 0 (26,177,000) 0 (26,177,000)
Balance at (in shares) at Dec. 31, 2013   71,305,375        
Balance at at Dec. 31, 2013   $ 71,000 303,710,000 (300,905,000) 256,000 3,132,000
Stock-based compensation expense   0 3,101,000 0 0 3,101,000
Issuance of common stock under stock option plan and employee stock purchase plan   $ 0 92,000 0 0 92,000
Issuance of common stock under stock option plan and employee stock purchase plan (in shares)   204,288        
Issuance of common stock under stock warrant agreement, net   $ 4,000 4,052,000 0 0 4,056,000
Issuance of common stock under stock warrant agreement, net (in shares)   4,042,733        
Sale of common stock, net   $ 8,000 18,582,000 0 0 18,590,000
Sale of common stock, net (in shares)   8,048,584        
Issuance of Series A preferred stock 3.6% Convertible Preferred Stock, net $ 0 $ 0 2,235,000 0 0 2,235,000
Issuance of Series A preferred stock 3.6% Convertible Preferred Stock, net (in shares) 13,500          
Conversion of Series A 3.6% Convertible Preferred Stock into common stock $ 0 $ 16,000 0 0 0 16,000
Conversion of Series A 3.6% Convertible Preferred Stock into common stock (in shares) (8,189) 15,747,397        
Accumulated other comprehensive income (loss)   $ 0 0 0 444,000 444,000
Net loss for the year ended   $ 0 0 (37,368,000) 0 $ (37,368,000)
Balance at (in shares) at Dec. 31, 2014 5,311 99,348,377       99,348,377
Balance at at Dec. 31, 2014   $ 99,000 331,772,000 (338,273,000) 700,000 $ (5,702,000)
Stock-based compensation expense   0 2,041,000 0 0 2,041,000
Issuance of common stock under stock option plan and employee stock purchase plan   $ 0 27,000     27,000
Issuance of common stock under stock option plan and employee stock purchase plan (in shares)   231,558        
Issuance of common stock under stock warrant agreement, net   $ 47,000 22,766,000 0 0 22,813,000
Issuance of common stock under stock warrant agreement, net (in shares)   46,853,649        
Sale of common stock, net   $ 39,000 10,662,000 0 0 10,701,000
Sale of common stock, net (in shares)   38,410,668        
Allocation of fair value for debt-related warrants   $ 0 776,000 0 0 776,000
Conversion of Series A 3.6% Convertible Preferred Stock into common stock   $ 10,000 (12,000) 0 0 (2,000)
Conversion of Series A 3.6% Convertible Preferred Stock into common stock (in shares) (5,311) 10,214,143        
Accumulated other comprehensive income (loss)   $ 0 0 0 296,000 296,000
Net loss for the year ended       (18,744,000) 0 $ (18,744,000)
Balance at (in shares) at Dec. 31, 2015 0 195,058,395       195,058,395
Balance at at Dec. 31, 2015   $ 195,000 $ 368,032,000 $ (357,017,000) $ 996,000 $ 12,206,000