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Quarterly Information (unaudited) (Details) - USD ($)
 3 Months Ended 12 Months Ended
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Quarterly Information (unaudited) [Abstract]                      
Product revenues $ 1,556,000 $ 766,000 $ 1,614,000 $ 902,000 $ 2,469,000 $ 518,000 $ 935,000 $ 1,031,000 $ 4,838,000 $ 4,953,000 $ 7,122,000
Gross profit 765,000 264,000 318,000 305,000 1,053,000 181,000 169,000 610,000 1,652,000 2,013,000 3,701,000
Development revenues 1,820,000 1,710,000 1,847,000 1,444,000 1,301,000 585,000 356,000 403,000 6,821,000 2,645,000 5,074,000
Operating expenses (4,656,000) 16,000 3,626,000 (22,745,000) (6,669,000) (8,656,000) (11,210,000) (10,560,000) 23,759,000 37,095,000 39,454,000
Other income (expense) (685,000) (470,000) (1,342,000) (961,000) (1,440,000) (1,495,000) (1,143,000) (853,000) (3,458,000) (4,931,000) 4,502,000
Net loss for the year ended (2,756,000) 1,520,000 4,449,000 (21,957,000) (5,755,000) (9,385,000) (11,828,000) (10,400,000) (18,744,000) (37,368,000) (26,177,000)
Beneficial conversion feature for convertible preferred stock 0 0 0 (661,000) (1,169,000) 0 0 0 (661,000) (1,169,000) 0
Net income (loss) allocable to common stock holders $ (2,756,000) $ 1,520,000 $ 4,449,000 $ (22,618,000) $ (6,924,000) $ (9,385,000) $ (11,828,000) $ (10,400,000) $ (19,405,000) $ (38,537,000) $ (26,177,000)
Basic and diluted net loss per share (in dollars per share) $ (0.02) $ 0.01 $ 0.03 $ (0.21) $ (0.08) $ (0.12) $ (0.15) $ (0.14) $ (0.14) $ (0.48) $ (0.39)