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Income Taxes (Details) - USD ($)
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Reconciliation of the total income tax provision tax rate [Abstract]      
Income tax expense (benefit) at federal statutory rate (34.00%) (34.00%) (34.00%)
Income tax expense (benefit) at state statutory rate (4.40%) (3.52%) (3.54%)
Gain on previously held equity interest in joint venture 0.00% 0.00% (7.02%)
Mark to market permanent adjustment (13.91%) (0.37%) (2.15%)
Change in valuation allowance (7.45%) 27.12% 80.13%
Change in state rate (0.09%) 0.02% (1.01%)
Permanent interest adjustments 6.25% 4.17% 0.00%
Stock compensation 20.43% 0.00% 0.00%
Transfer pricing 18.49% 0.00% 0.00%
Debt refinance permanent adjustment 0.00% 3.92% 0.00%
Acquired NOL's/Intangibles from joint venture 0.00% 0.00% (33.40%)
Research credit (2.37%) (0.74%) (3.75%)
Foreign rate differential 0.69% 0.00% 2.48%
NOLs expiring 13.92% 0.00% 0.00%
Other, net 2.44% 3.40% 2.26%
Total income tax provision 0.00% 0.00% 0.00%
Deferred tax assets [Abstract]      
Allowances and reserves $ 673,000 $ 825,000  
Accrued expenses 951,000 502,000  
Deferred revenue and gain-on-sale 39,000 32,000  
Stock based compensation 4,547,000 7,786,000  
Net operating loss carryforwards 119,000,000 117,258,000  
Income tax credit carryforwards 7,437,000 6,993,000  
Property and equipment, principally due to differences in depreciation 683,000 926,000  
Other, net 16,000 77,000  
Deferred tax assets (Total) 133,346,000 134,399,000  
Valuation allowance (131,187,000) (132,583,000)  
Total deferred tax assets, net of allowance 2,159,000 1,816,000  
Deferred tax liabilities [Abstract]      
Intangibles (2,159,000) (1,816,000)  
Total deferred tax liability (2,159,000) (1,816,000)  
Net deferred tax assets (liability) 0 0  
Schedule of reconciliation of unrecognized tax benefits activity [Roll Forward]      
Unrecognized Tax Benefits - Beginning 1,852,000 1,723,000 $ 1,394,000
Gross increases - tax positions in prior period 0 0 69,000
Gross decreases - tax positions in prior period 0 0 0
Gross increase - current-period tax positions 135,000 129,000 260,000
Settlements 0 0 0
Lapse of statute of limitations 0 0 0
Unrecognized Tax Benefits - Ending 1,987,000 $ 1,852,000 $ 1,723,000
Income Tax Contingency [Line Items]      
Decrease in valuation allowance $ (1,396,000)    
Net operating loss carryforwards, Expire date Begin to expire in 2019 and 2016    
State tax credit carryforwards $ 4,271,000    
Cumulative change in ownership 50.00%    
Period of net operating loss and R&D tax credit carry forwards to offset future taxable income 3 years    
Excess tax benefits $ 1,265,000    
Period for material changes of liability for uncertain tax benefits 12 months    
Federal [Member]      
Income Tax Contingency [Line Items]      
Tax loss carryforwards $ 323,938,000    
Federal tax carry forward $ 4,618,000    
Federal tax credit carryforward, Expiration date Begin to expire in 2018    
California [Member]      
Income Tax Contingency [Line Items]      
Tax loss carryforwards $ 166,612,000