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Stockholders' Equity (Details)
1 Months Ended 3 Months Ended 12 Months Ended
Dec. 17, 2015
shares
Aug. 27, 2015
USD ($)
$ / shares
shares
May. 08, 2015
USD ($)
$ / shares
Jun. 04, 2014
USD ($)
$ / shares
May. 14, 2014
shares
May. 31, 2015
USD ($)
Closing
$ / shares
shares
Oct. 31, 2014
USD ($)
$ / shares
shares
Sep. 30, 2014
USD ($)
WarrantHolder
$ / shares
shares
May. 31, 2014
USD ($)
WarrantHolder
$ / shares
shares
Jan. 31, 2014
USD ($)
Oct. 31, 2013
Closing
$ / shares
shares
Jan. 31, 2013
USD ($)
shares
Jun. 30, 2015
USD ($)
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
$ / shares
shares
Dec. 31, 2013
USD ($)
May. 14, 2015
$ / shares
Mar. 31, 2015
USD ($)
Sep. 10, 2014
$ / shares
Preferred Stock [Abstract]                                      
Preferred stock, shares authorized (in shares)                           5,000,000          
Preferred stock, par value (in dollars per share) | $ / shares                           $ 0.001          
Common Stock [Abstract]                                      
Proceeds from private placement of stock | $             $ 4.9         $ 3,000,000              
Common stock, shares authorized (in shares)                           290,000,000 290,000,000        
Period exercisable from the date of issuance             6 years 6 years                      
Number of warrant holders | WarrantHolder               13 47                    
Number of shares called by warrants (in shares)               4 3,156,238     1,053,000              
Warrant exercise price (in dollars per share) | $ / shares       $ 3.00       $ 2.00 $ 2.62         $ 0.75 $ 0.69   $ 3.50   $ 1.00
Number of holders who did not agree to Amendment | WarrantHolder                 1                    
Number of shares called by warrants that expired unexercised (in shares)         38,500                            
Conversion price (in dollars per share) | $ / shares             $ 0.52                        
Percentage of shares equal to purchase of warrants             100.00%                        
Period in which warrants will expire               5 years                      
Warrants with reduced exercise price (in shares)             3,400,000                        
Proceeds from exercise of warrants | $               $ 4,000,000                      
Warrants exercised (in shares)                           0          
Common stock issued, value | $                           $ 10,701,000 $ 18,590,000 $ 17,816,000      
Warrants [Member]                                      
Common Stock [Abstract]                                      
Warrants exercised (in shares)                           3,400,000          
October 2014 Warrants [Member]                                      
Common Stock [Abstract]                                      
Proceeds from exercise of warrants | $                         $ 4,900,000            
Warrants exercised (in shares)                         8,500,000            
May 2015 Warrants [Member]                                      
Common Stock [Abstract]                                      
Period exercisable from the date of issuance           6 years                          
Each unit consist of number of common stock and warrant (in shares)           1                          
Warrant exercise price (in dollars per share) | $ / shares           $ 1.02                          
Period in which warrants will expire           5 years                          
August 2015 Warrants [Member]                                      
Common Stock [Abstract]                                      
Warrant exercise price (in dollars per share) | $ / shares   $ 0.401                                  
Period in which warrants will expire   5 years                                  
2015 Amendment [Member]                                      
Common Stock [Abstract]                                      
Shares received per warrant (in shares) 0.75                                    
2014 Amendment [Member]                                      
Common Stock [Abstract]                                      
Shares received per warrant (in shares) 0.69                                    
WBB Securities, LLC [Member]                                      
Common Stock [Abstract]                                      
Number of shares called by warrants (in shares)                 202,429                    
Warrant exercise price (in dollars per share) | $ / shares                 $ 3.09                    
Institutional Investors [Member]                                      
Common Stock [Abstract]                                      
Proceeds from private placement of stock | $       $ 10,000,000                              
Common stock issued (in shares)   7,499,993         13,500                        
Common stock, shares authorized (in shares)   14,999,993                                  
Sale of stock, price per share (in dollars per share) | $ / shares             $ 1,000                        
Each unit consist of number of common stock and warrant (in shares)             1                        
Warrant exercise price (in dollars per share) | $ / shares             $ 0.5771                        
Period in which warrants will expire             5 years                        
Institutional Investors [Member] | May 2015 Warrants [Member]                                      
Common Stock [Abstract]                                      
Proceeds from private placement of stock | $     $ 17.4                                
Common stock at a purchase price (in dollars per unit) | $ / shares     $ 0.77           $ 2.47                    
Number of closings | Closing           2                          
Each unit consist of number of common stock and warrant (in shares)           1     1                    
Warrant exercise price (in dollars per share) | $ / shares                 $ 3.00                    
Common stock issued, value | $           $ 25,000,000     $ 4,048,584                    
Institutional Investors [Member] | August 2015 Warrants [Member]                                      
Common Stock [Abstract]                                      
Proceeds from private placement of stock | $   $ 2.1                                  
Common stock at a purchase price (in dollars per unit) | $ / shares   $ 0.3263                                  
Lorem Vascular [Member]                                      
Common Stock [Abstract]                                      
Proceeds from private placement of stock | $                               15,000,000      
Common stock issued (in shares)                     8,000,000                
Sale of stock, price per share (in dollars per share) | $ / shares                     $ 3.00                
Number of closings | Closing                     2                
Lorem Vascular [Member] | First Closing of Stock sale [Member]                                      
Common Stock [Abstract]                                      
Proceeds from private placement of stock | $                               12,000,000      
Common stock issued (in shares)                     4,000,000                
Lorem Vascular [Member] | Second Closing of Stock sale [Member]                                      
Common Stock [Abstract]                                      
Proceeds from private placement of stock | $                               $ 3,000,000      
Common stock issued (in shares)                     4,000,000                
Receivables from sale of stock | $                   $ 9,000,000                  
Series A Preferred Stock [Member]                                      
Preferred Stock [Abstract]                                      
Preferred stock, shares authorized (in shares)                           5,000,000 5,000,000        
Preferred stock, par value (in dollars per share) | $ / shares                           $ 0.001 $ 0.001        
Preferred stock, shares outstanding (in shares)                           0 5,311        
Preferred stock, shares issued (in shares)                           13,500 13,500        
Convertible preferred stock                           3.60% 3.60%        
Common Stock [Abstract]                                      
Cashless exercise of warrants | $                           $ 1,800,000          
Proceeds from exercise of warrants | $                           $ 100,000          
Series A Preferred Stock [Member] | Dividend Declared [Member]                                      
Common Stock [Abstract]                                      
Dividends Payable | $                             $ 70,000        
Series A Preferred Stock [Member] | Dividend Paid [Member]                                      
Common Stock [Abstract]                                      
Dividends Payable | $                             $ 1,200,000     $ 700,000  
Warrants [Member]                                      
Common Stock [Abstract]                                      
Warrant exercise price (in dollars per share) | $ / shares           $ 0.3263               $ 0.5771