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Liquidity (Details) - USD ($)
 3 Months Ended 6 Months Ended
Jun. 16, 2016
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Jun. 15, 2016
May 10, 2016
Mar. 31, 2016
Dec. 31, 2015
Liquidity [Abstract]                  
Net loss   $ (6,405,000) $ 4,450,000 $ (11,743,000) $ (17,509,000)        
Accumulated deficit   $ 368,761,000   368,761,000         $ 357,017,000
Net cash used in operating activities       $ 10,735,000 $ 9,788,000        
Common stock issued (in shares) 6,704,852                
Common stock, shares outstanding (in shares)   20,492,601   20,492,601   6,704,852 13,300,000 200,000,000 13,003,893
Each unit consist of number of warrant 3,352,306                
Number of shares callable by warrants (in shares)           1 1,100,000 16,000,000  
Warrant exercise price (in dollars per share)           $ 3.06      
Proceeds from issuance warrants $ 17,100,000