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Stockholders' Equity (Details)
 1 Months Ended 12 Months Ended
Dec. 31, 2016
$ / shares
shares
Dec. 22, 2016
USD ($)
$ / shares
shares
Jun. 16, 2016
USD ($)
shares
Aug. 27, 2015
USD ($)
shares
May 08, 2015
USD ($)
May 31, 2015
USD ($)
Closing
shares
Dec. 31, 2016
USD ($)
$ / shares
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
Jun. 15, 2016
$ / shares
shares
May 11, 2016
shares
May 10, 2016
shares
Dec. 17, 2015
shares
Mar. 31, 2015
USD ($)
Preferred Stock [Abstract]                            
Preferred stock, shares authorized (in shares) 5,000,000           5,000,000 5,000,000            
Preferred stock, par value (in dollars per share) | $ / shares $ 0.001           $ 0.001 $ 0.001            
Preferred stock, shares issued (in shares) 13,500           13,500 13,500            
Convertible preferred stock             3.60% 3.60% 3.60%          
Series A convertible preferred stock, shares outstanding 0           0 0            
Common Stock [Abstract]                            
Common stock issued, value | $             $ 19,478,000 $ 10,701,000            
Number of shares callable by warrants (in shares)                   1 1,100,000 16,000,000    
Common stock issued (in shares)     6,704,852                      
Common stock, shares authorized (in shares) 75,000,000           75,000,000 75,000,000     75,000,000 290,000,000    
Proceeds from sale of common stock | $             $ 21,467,000 $ 29,054,000            
Each unit consist of number of warrant     3,352,306                      
Warrant exercise price (in dollars per share) | $ / shares                   $ 3.06        
Common Stock [Member]                            
Common Stock [Abstract]                            
Common stock issued, value | $             $ 9,000 $ 2,000            
Number of shares callable by warrants (in shares) 1           1              
Common stock issued (in shares)     6,704,852       8,673,253 2,560,711            
Common Stock Subscription Price | $ / shares             $ 2.55              
Each unit consist of number of common stock 1           1              
Each unit consist of number of warrant             0.5              
Warrant exercise price (in dollars per share) | $ / shares $ 3.06           $ 3.06              
Period exercisable from the date of issuance             30 months              
Gross proceeds from private placement of stock | $     $ 15,300,000                      
Redemption price of warrant prior to expiration | $ / shares $ 0.01           $ 0.01              
Common stock price per share for warrant redemption | $ / shares             $ 7.65              
Number of consecutive trading days for warrant redemption             10 days              
Common Stock [Member] | Lincoln Park Capital Fund, LLC [Member]                            
Common Stock [Abstract]                            
Common stock issued, value | $   $ 20,000,000                        
Period exercisable from the date of issuance   30 months                        
Common Stock [Member] | Purchase Agreement [Member] | Lincoln Park Capital Fund, LLC [Member]                            
Common Stock [Abstract]                            
Common stock issued, value | $   $ 200,000                        
Common stock issued (in shares) 0                          
Common Stock [Member] | Maximum [Member] | Purchase Agreement [Member] | Lincoln Park Capital Fund, LLC [Member]                            
Common Stock [Abstract]                            
Floor price of per share | $ / shares   $ 0.50                        
Common Stock [Member] | Minimum [Member] | Lincoln Park Capital Fund, LLC [Member]                            
Common Stock [Abstract]                            
Beneficial ownership percentage of common stock outstanding   9.99%                        
Common Stock [Member] | 2015 Amendment [Member]                            
Common Stock [Abstract]                            
Number of shares callable by each warrant (in shares)                         0.75  
Common Stock [Member] | 2014 Amendment [Member]                            
Common Stock [Abstract]                            
Number of shares callable by each warrant (in shares)                         0.69  
ATM [Member]                            
Common Stock [Abstract]                            
Common stock issued (in shares)             1,840,982 5,800,000            
Proceeds from sale of common stock | $             $ 4,400,000 $ 7,200,000            
Securities Purchase Agreement [Member]                            
Common Stock [Abstract]                            
Common stock issued, value | $           $ 25,000,000                
Number of closings | Closing           2                
Securities Purchase Agreement [Member] | Initial Closing [Member]                            
Common Stock [Abstract]                            
Proceeds from private placement of stock | $         $ 17,400,000                  
Securities Purchase Agreement [Member] | Second Closing [Member]                            
Common Stock [Abstract]                            
Proceeds from private placement of stock | $       $ 2,100,000                    
Common stock issued (in shares)       500,000                    
Common stock, shares authorized (in shares)       1,000,000                    
Securities Purchase Agreement [Member] | Common Stock [Member]                            
Common Stock [Abstract]                            
Number of shares callable by warrants (in shares)           1                
Number of shares callable by each warrant (in shares)           1                
Securities Purchase Agreement [Member] | Common Stock [Member] | Lincoln Park Capital Fund, LLC [Member]                            
Common Stock [Abstract]                            
Common stock issued (in shares)   127,419                        
Trading Volume of Common Shares   0                        
Common stock issued (in shares)   382,258                        
Securities Purchase Agreement [Member] | Warrant [Member]                            
Common Stock [Abstract]                            
Number of shares callable by warrants (in shares)           1                
Single Regular Purchase [Member] | Common Stock [Member] | Maximum [Member] | Lincoln Park Capital Fund, LLC [Member]                            
Common Stock [Abstract]                            
Common stock issued (in shares)   100,000                        
Single Regular Purchase [Member] | Common Stock [Member] | Minimum [Member] | Lincoln Park Capital Fund, LLC [Member]                            
Common Stock [Abstract]                            
Common stock issued, value | $   $ 1,000,000                        
Dividend Paid [Member]                            
Preferred Stock [Abstract]                            
Dividends payable | $                           $ 700,000
Dividend Declared [Member]                            
Preferred Stock [Abstract]                            
Dividends payable | $                 $ 70,000