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Stock-based Compensation - Stock Option Activity (Details)
 12 Months Ended
Dec. 31, 2016
$ / shares
shares
Options [Roll Forward]  
Balance as of January 1, 2016 (in shares) | shares 573,727
Granted (in shares) | shares 347,407
Expired (in shares) | shares (23,979)
Cancelled/forfeited (in shares) | shares (261,043)
Balance as of December 31, 2016 (in shares) | shares 636,112
Weighted Average Exercise Price [Roll Forward]  
Balance as of January 1, 2016 (in dollars per share) | $ / shares $ 44.85
Granted (in dollars per share) | $ / shares 2.73
Expired (in dollars per share) | $ / shares 104.11
Cancelled/forfeited (in dollars per share) | $ / shares 32.07
Balance as of December 31, 2016 (in dollars per share) | $ / shares $ 24.39