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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Cash flows from operating activities:    
Net loss $ (22,046) $ (18,744)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,182 1,093
Amortization of deferred financing costs and debt discount 954 979
Joint Venture acquisition obligation accretion 24 365
Provision for doubtful accounts 0 (105)
Provision for expired inventory 172 0
Change in fair value of warrants 0 (7,668)
Share-based compensation expense 1,080 2,041
(Gain) loss on asset disposal (127) 8
Loss on debt extinguishment 0 260
Increases (decreases) in cash caused by changes in operating assets and liabilities:    
Accounts receivable (179) 328
Inventories 471 490
Other current assets 633 (637)
Other assets (764) 363
Accounts payable and accrued expenses (673) 1,045
Deferred revenues (8) 3
Long-term deferred rent (252) (289)
Net cash used in operating activities (19,533) (20,468)
Cash flows from investing activities:    
Purchases of property and equipment (67) (611)
Expenditures for intellectual property 0 (13)
Proceeds from sale of assets 131 11
Net cash provided by (used in) investing activities 64 (613)
Cash flows from financing activities:    
Principal payments on long-term obligations 0 (25,032)
Proceeds from long-term obligations 0 17,700
Debt issuance costs and loan fees 0 (1,854)
Joint Venture purchase payments (1,774) (1,623)
Proceeds from exercise of employee stock options and warrants 0 4,997
Proceeds from sale of common stock 21,467 29,054
Costs from sale of common stock 2,084 2,370
Dividends paid on preferred stock 0 (75)
Net cash provided by financing activities 17,609 20,797
Effect of exchange rate changes on cash and cash equivalents 82 0
Net decrease in cash and cash equivalents (1,778) (284)
Cash and cash equivalents at beginning of period 14,338 14,622
Cash and cash equivalents at end of period 12,560 14,338
Cash paid during period for:    
Interest 1,618 1,994
Final payment fee on long-term debt 0 1,839
Supplemental schedule of non-cash investing and financing activities:    
Issuance costs paid in common stock 189 0
Conversion of preferred stock into common stock 0 10
Declared dividend related to preferred stock 0 3
Fair value of warrants allocated to additional paid-in capital $ 0 $ 776