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Quarterly Information (unaudited) (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2016	Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract]
Product revenues	$ 1,466	$ 731	$ 1,126	$ 1,333	$ 1,556	$ 766	$ 1,614	$ 902	$ 4,656	$ 4,838
Gross profit	521	113	541	766	765	264	318	305	1,941	1,652
Development revenues	1,561	1,879	1,699	1,585	1,820	1,710	1,847	1,444
Operating expenses	(5,670)	(6,789)	(8,464)	(7,448)	(4,656)	16	3,626	(22,745)
Other expense, net	(1,330)	(587)	(181)	(242)	(685)	(470)	(1,342)	(961)	(2,340)	(3,458)
Net loss	(4,918)	(5,384)	(6,405)	(5,339)	(2,756)	1,520	4,449	(21,957)	(22,046)	(18,744)
Beneficial conversion feature for convertible preferred stock	0	0	0	0	0	0	0	(661)	0	(661)
Net loss allocable to common stockholders	$ (4,918)	$ (5,384)	$ (6,405)	$ (5,339)	$ (2,756)	$ 1,520	$ 4,449	$ (22,618)	$ (22,046)	$ (19,405)
Basic and diluted net loss per share	$ (0.24)	$ (0.26)	$ (0.43)	$ (0.41)	$ (0.25)	$ 0.15	$ 0.45	$ (3.19)	$ (1.28)	$ (2.07)

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Aggregate revenue earned during the period from recognition of related party deferred revenue, non-product related activities and revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements.

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Aggregate revenue less cost of goods and services sold or operating expenses directly attributable to the revenue generation activity.

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Net income after adjustments for dividends on preferred stock (declared in the period) and/or cumulative preferred stock (accumulated for the period).

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Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

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