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Liquidity (Details) - USD ($)
 3 Months Ended
Apr. 11, 2017
Jun. 16, 2016
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Jun. 15, 2016
May 11, 2016
May 10, 2016
Dec. 31, 2015
Liquidity [Line Items]                  
Net loss     $ 7,544,000 $ 5,339,000          
Accumulated deficit     386,607,000   $ 379,063,000        
Net cash used in operating activities     4,827,000 5,058,000          
Cash and cash equivalents     6,255,000 9,358,000 $ 12,560,000       $ 14,338,000
Payments of principal amount in monthly installments     600,000            
Minimum cash/cash equivalents covenant     $ 5,000,000            
Common stock issued (in shares)   6,704,852              
Common stock, par value (in dollars per share)     $ 0.001   $ 0.001        
Proceeds from sale of common stock, net     $ 1,435,000 $ 562,000          
Each unit consist of number of warrant   3,352,306              
Number of shares callable by warrants (in shares)           1 1,100,000 16,000,000  
Warrant exercise price (in dollars per share)           $ 3.06      
Proceeds from issuance warrants   $ 17,100,000              
Common Stock [Member]                  
Liquidity [Line Items]                  
Common stock issued (in shares)   6,704,852              
Each unit consist of number of warrant     0.5            
Number of shares callable by warrants (in shares)     1            
Warrant exercise price (in dollars per share)     $ 3.06            
Common Stock [Member] | Subsequent Event [Member]                  
Liquidity [Line Items]                  
Share issued, price per share $ 1.10                
Common Stock [Member] | Subsequent Event [Member] | Maxim Group LLC [Member]                  
Liquidity [Line Items]                  
Common stock issued (in shares) 8,600,000                
Common stock, par value (in dollars per share) $ 0.001                
Share issued, price per share $ 1.0395                
Proceeds from sale of common stock, net $ 8,700,000                
Closing of offering date Apr. 17, 2017                
Number of days granted as option to purchase additional shares of common stock to underwriter 45 days                
Additional shares of common stock 944,000                
Minimum [Member]                  
Liquidity [Line Items]                  
Unrestricted cash and cash equivalents     $ 5,000,000