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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Series B Convertible Preferred Stock [Member] | Convertible Preferred Stock [Member] | Convertible Preferred Stock [Member] Series B Convertible Preferred Stock [Member] | Common Stock [Member] | Common Stock [Member] Series B Convertible Preferred Stock [Member] | Additional Paid-in Capital [Member] | Additional Paid-in Capital [Member] Series B Convertible Preferred Stock [Member] | Accumulated Other Comprehensive Income [Member] | Accumulated Deficit [Member]
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2015 | $ 12,206 |  |  |  | $ 13 |  | $ 368,214 |  | $ 996 | $ (357,017)
Balance (in shares) at Dec. 31, 2015 |  |  |  |  | 13,003,893 |  |  |  |  |
Share-based compensation | 1,080 |  |  |  |  |  | 1,080 |  |  |
Issuance of common stock under employee stock purchase plan | 6 |  |  |  |  |  | 6 |  |  |
Issuance of common stock under employee stock purchase plan (in shares) |  |  |  |  | 30,744 |  |  |  |  |
Sale/Issuance of common stock | 19,478 |  |  |  | $ 9 |  | 19,469 |  |  |
Sale/Issuance of common stock (in shares) |  |  |  |  | 8,673,253 |  |  |  |  |
Foreign currency translation adjustment and accumulated other comprehensive income | 262 |  |  |  |  |  |  |  | 262 |
Net loss | (22,046) |  |  |  |  |  |  |  |  | (22,046)
Balance at Dec. 31, 2016 | $ 10,986 |  |  |  | $ 22 |  | 388,769 |  | 1,258 | (379,063)
Balance (in shares) at Dec. 31, 2016 | 21,707,890 |  |  |  | 21,707,890 |  |  |  |  |
Share-based compensation | $ 753 |  |  |  |  |  | 753 |  |  |
Issuance of common stock under employee stock purchase plan | 1 |  |  |  |  |  | 1 |  |  |
Issuance of common stock under employee stock purchase plan (in shares) |  |  |  |  | 1,200 |  |  |  |  |
Sale/Issuance of common stock | 12,716 | $ 8,767 |  |  | $ 12 |  | 12,704 | $ 8,767 |  |
Sale/Issuance of common stock (in shares) |  |  |  | 10,000 | 12,237,079 |  |  |  |  |
Conversion of Series B Convertible Preferred Stock into common stock |  | 23 |  |  |  | $ 23 |  |  |  |
Conversion of Series B Convertible Preferred Stock into common stock (share) |  |  |  | (7,569) |  | 22,706,319 |  |  |  |
Issuance of common stock as part of Azaya Therapeutics acquisition, net | 2,311 |  |  |  | $ 1 |  | 2,310 |  |  |
Issuance of common stock as part of Azaya Therapeutics acquisition, net (shares) |  |  |  |  | 1,173,241 |  |  |  |  |
Beneficial conversion feature related to Series B Convertible Preferred Stock |  | 3,977 |  |  |  |  |  | 3,977 |  |
Accretion of beneficial conversion feature related to Series B Convertible Preferred Stock |  | $ (3,977) |  |  |  |  |  | $ (3,977) |  |
Foreign currency translation adjustment and accumulated other comprehensive income | 129 |  |  |  |  |  |  |  | 129 |
Net loss | (22,686) |  |  |  |  |  |  |  |  | (22,686)
Balance at Dec. 31, 2017 | $ 13,000 |  |  |  | $ 58 |  | $ 413,304 |  | $ 1,387 | $ (401,749)
Balance (in shares) at Dec. 31, 2017 | 57,825,729 |  | 2,431 |  | 57,825,729 |  |  |  |  |

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