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Composition of Certain Financial Statement Captions - Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
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Accounts Payable and Accrued Expenses [Abstract] |  |
Accrued expenses | $ 1,599 | $ 1,752
Accounts payable | 1,297 | 1,332
Accrued payroll and bonus | 810 | 989
Accrued legal fees | 509 | 614
Accrued vacation | 64 | 502
Accrued R&D studies | 286 | 347
Other current liabilities | 225 | 336
Accounts payable and accrued expenses, Total | $ 4,790 | $ 5,872

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