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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016
Cash flows from operating activities: |  |
Net loss | $ (22,686) | $ (22,046)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 2,151 | 1,182
Amortization of deferred financing costs and debt discount | 707 | 954
Joint venture acquisition obligation accretion | 0 | 24
Provision for expired inventory | 340 | 172
Share-based compensation expense | 753 | 1,080
Gain on asset disposal | (42) | (127)
Increases (decreases) in cash caused by changes in operating assets and liabilities: |  |
Accounts receivable | 1,129 | (179)
Inventories | 251 | 471
Other current assets | (593) | 633
Other assets | (94) | (764)
Accounts payable and accrued expenses | (1,817) | (673)
Deferred revenues | (3) | (8)
Long-term deferred rent | 90 | (252)
Net cash used in operating activities | (18,128) | (19,533)
Cash flows from investing activities: |  |
Purchases of property and equipment /long-lived assets | (295) | (67)
Proceeds from sale of assets | 113 | 131
Change in restricted cash | (325) | 0
Net cash (used in) provided by investing activities | (1,708) | 64
Cash flows from financing activities: |  |
Principal payments on long-term obligations | (4,720) | 0
Joint venture purchase payments | 0 | (1,774)
Proceeds from sale of common stock | 23,613 | 21,467
Costs from sale of common stock | (2,078) | (2,084)
Net cash provided by financing activities | 16,815 | 17,609
Effect of exchange rate changes on cash and cash equivalents | 11 | 82
Net decrease in cash and cash equivalents | (3,010) | (1,778)
Cash and cash equivalents at beginning of period | 12,560 | 14,338
Cash and cash equivalents at end of period | 9,550 | 12,560
Cash paid during period for: |  |
Interest | 1,364 | 1,618
Supplemental schedule of non-cash investing and financing activities: |  |
Issuance costs paid in common stock | 0 | 189
Conversion of preferred stock into common stock | 23 | 0
Fair value of Series B Convertible Preferred Stock beneficial conversion feature | 3,977 | 0
Azaya Therapeutics, Inc. [Member] |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |
In process research and development acquired from Azaya Therapeutics | 1,686 | 0
Cash flows from investing activities: |  |
Purchases of property and equipment /long-lived assets | (1,201) | 0
Supplemental schedule of non-cash investing and financing activities: |  |
Common stock issued in payment for the assets acquired | $ 2,311 | $ 0

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- Definition The amount of purchased research and development assets that are acquired in a business combination have no alternative future use and are therefore written off in the period of acquisition. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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