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Quarterly Information (unaudited) (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016
Quarterly Financial Information Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Product revenues | $ 662 | $ 467 | $ 969 | $ 591 | $ 1,466 | $ 731 | $ 1,126 | $ 1,333 | $ 2,689 | $ 4,656
Gross profit | 29 | (20) | 262 | (125) | 521 | 113 | 541 | 766 | 146 | 1,941
Development revenues | 867 | 1,306 | 531 | 1,018 | 1,561 | 1,879 | 1,699 | 1,585 |  |
Operating expenses | (4,526) | (5,629) | (6,374) | (6,336) | (5,670) | (6,789) | (8,464) | (7,448) |  |
Other expense, net | (656) | (464) | (468) | (415) | (1,330) | (587) | (181) | (242) | (2,003) | (2,340)
Net loss | (4,286) | (4,807) | (6,049) | (7,544) | (4,918) | (5,384) | (6,405) | (5,339) | (22,686) | (22,046)
Beneficial conversion feature for convertible preferred stock | (3,977) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | (3,977) | 0
Net loss allocable to common stockholders | $ (8,263) | $ (4,807) | $ (6,049) | $ (7,544) | $ (4,918) | $ (5,384) | $ (6,405) | $ (5,339) | $ (26,663) | $ (22,046)
Basic and diluted net loss per share | $ (0.20) | $ (0.14) | $ (0.19) | $ (0.33) | $ (0.24) | $ (0.26) | $ (0.43) | $ (0.41) | $ (0.82) | $ (1.28)
Azaya Therapeutics, Inc. [Member] |  |  |  |  |  |  |  |  |  |
Quarterly Financial Information Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
In process research and development acquired from Azaya |  |  |  | $ (1,686) |  |  |  |  | $ (1,686) | $ 0

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