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Organization and Operations - Additional Information (Details) |  |  |  |  |  |  |  | 3 Months Ended | 12 Months Ended |  |  |
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Nov. 28, 2017 USD ($) $ / shares shares | Sep. 05, 2017 $ / shares | May 31, 2017 USD ($) $ / shares shares | Apr. 11, 2017 USD ($) $ / shares shares | Dec. 22, 2016 USD ($) | Jun. 16, 2016 USD ($) shares | May 10, 2016 shares | Dec. 31, 2017 USD ($) $ / shares shares | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) $ / shares shares | Sep. 30, 2016 USD ($) | Jun. 30, 2016 USD ($) | Mar. 31, 2016 USD ($) | Dec. 31, 2017 USD ($) Subsidiary $ / shares shares | Dec. 31, 2016 USD ($) $ / shares shares | Jun. 15, 2016 $ / shares shares | May 11, 2016 shares | Dec. 31, 2015 USD ($) shares
Basis Of Presentation And New Accounting Standards [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of wholly-owned subsidiaries | Subsidiary |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 |  |  |  |
Reverse stock split of common stock |  |  |  |  |  |  | 15 |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares outstanding (in shares) |  |  |  |  |  |  | 200,000,000 | 57,825,729 |  |  |  | 21,707,890 |  |  |  | 57,825,729 | 21,707,890 |  | 13,300,000 |
Number of shares callable by warrants (in shares) |  |  |  |  |  |  | 16,000,000 |  |  |  |  |  |  |  |  |  |  | 1 | 1,100,000 |
Common stock, shares authorized (in shares) |  |  |  |  |  |  | 290,000,000 | 75,000,000 |  |  |  | 75,000,000 |  |  |  | 75,000,000 | 75,000,000 |  | 75,000,000 |
Net loss | $ |  |  |  |  |  |  |  | $ 4,286,000 | $ 4,807,000 | $ 6,049,000 | $ 7,544,000 | $ 4,918,000 | $ 5,384,000 | $ 6,405,000 | $ 5,339,000 | $ 22,686,000 | $ 22,046,000 |  |  |
Accumulated deficit | $ |  |  |  |  |  |  |  | (401,749,000) |  |  |  | (379,063,000) |  |  |  | (401,749,000) | (379,063,000) |  |  |
Net cash used in operating activities | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (18,128,000) | (19,533,000) |  |  |
Substantial doubt about going concern, description |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | The Company does not have sufficient capital to fund operations through one year from the issuance date of these consolidated financial statements. These factors raise substantial doubt about the Company’s ability to continue as a going concern. |  |  |  |
Cash and cash equivalents | $ |  |  |  |  |  |  |  | 9,550,000 |  |  |  | $ 12,560,000 |  |  |  | $ 9,550,000 | 12,560,000 |  |  | $ 14,338,000
Minimum cash/cash equivalents covenant | $ |  |  |  |  |  |  |  | $ 1,500,000 |  |  |  |  |  |  |  | 1,500,000 |  |  |  |
Common stock issued (in shares) | 10,000 |  |  |  |  | 6,704,852 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Each unit consist of number of warrant |  |  |  |  |  | 3,352,306 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3.06 |  |
Proceeds from issuance warrants | $ | $ 8,800,000 |  |  |  |  | $ 17,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, value | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12,716,000 | $ 19,478,000 |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.001 |  |  |  | $ 0.001 |  |  |  | $ 0.001 | $ 0.001 |  |  |
Proceeds from sale of common stock, net | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 23,613,000 | $ 21,467,000 |  |  |
Series B Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis Of Presentation And New Accounting Standards [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares callable by warrants (in shares) | 18,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued (in shares) | 30,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, value | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,767,000 |  |  |  |
Nasdaq Stock Market LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis Of Presentation And New Accounting Standards [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of consecutive business days no longer able to meet the required closing bid price of common stock |  | 30 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Minimum bid price of common stock required for Nasdaq listing rule | $ / shares |  | $ 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Grace period provided with minimum bid price for Nasdaq listing rule |  | 180 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Grace date for minimum bid price requirement for Nasdaq listing |  | Mar. 05, 2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock minimum bid price required to regain compliance | $ / shares |  | $ 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of consecutive business days required to regain compliance |  | 10 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional grace period provided with minimum bid price to regain compliance |  | 180 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Date to regain compliance after meeting continued listing requirement |  | Sep. 04, 2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis Of Presentation And New Accounting Standards [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares outstanding (in shares) |  |  |  |  |  |  |  | 57,825,729 |  |  |  | 21,707,890 |  |  |  | 57,825,729 | 21,707,890 |  |  | 13,003,893
Number of shares callable by warrants (in shares) |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | 1 |  |  |  |
Common stock issued (in shares) | 10,000 |  |  |  |  | 6,704,852 |  |  |  |  |  |  |  |  |  | 12,237,079 | 8,673,253 |  |  |
Each unit consist of number of warrant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.5 |  |  |  |
Warrant exercise price (in dollars per share) | $ / shares | $ 0.3333 |  |  |  |  |  |  | $ 3.06 |  |  |  |  |  |  |  | $ 3.06 |  |  |  |
Common stock issued, value | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12,000 | $ 9,000 |  |  |
Period exercisable from the date of issuance |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 30 months |  |  |  |
Share issued, price per share | $ / shares |  |  |  | $ 1.10 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock [Member] | Maxim Group LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis Of Presentation And New Accounting Standards [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued (in shares) |  |  | 849,000 | 8,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  | $ 0.001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share issued, price per share | $ / shares |  |  | $ 1.10 | $ 1.0395 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from sale of common stock, net | $ |  |  | $ 800,000 | $ 8,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Closing of offering date |  |  |  | Apr. 17, 2017 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of days granted as option to purchase additional shares of common stock to underwriter |  |  |  | 45 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional shares of common stock |  |  |  | 944,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock [Member] | Lincoln Park Capital Fund, LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis Of Presentation And New Accounting Standards [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, value | $ |  |  |  |  | $ 20,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period exercisable from the date of issuance |  |  |  |  | 30 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis Of Presentation And New Accounting Standards [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrestricted cash and cash equivalents | $ |  |  |  |  |  |  |  | $ 1,500,000 |  |  |  |  |  |  |  | $ 1,500,000 |  |  |  |
2014 Equity Incentive Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis Of Presentation And New Accounting Standards [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares callable by warrants (in shares) |  |  |  |  |  |  | 6,500,000 |  |  |  |  |  |  |  |  |  |  |  | 400,000 |

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