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Commitments and Contingencies (Details) - USD ($) $ in Thousands |  |  | 12 Months Ended
--- | --- | --- | ---
Feb. 27, 2017 | Jan. 27, 2017 | Dec. 31, 2017 | Dec. 31, 2016
Recorded Unconditional Purchase Obligation [Line Items] |  |  |  |
Contractual obligation, due in next twelve months |  |  | $ 5,192 |
Initial term of lease | 63 months |  |  |
Lease commencement date | Jan. 01, 2018 |  |  |
Buy-out of obligations lease | $ 600 |  |  |
Japan Lease [Member] |  |  |  |
Recorded Unconditional Purchase Obligation [Line Items] |  |  |  |
Initial term of lease |  | 61 months |  |
Lease commencement date |  |  | Apr. 15, 2017 |
Pre-clinical Research Study Obligations [Member] |  |  |  |
Recorded Unconditional Purchase Obligation [Line Items] |  |  |  |
Contractual obligation, due in next twelve months |  |  | $ 600 |
Operating Lease Obligations [Member] |  |  |  |
Recorded Unconditional Purchase Obligation [Line Items] |  |  |  |
Rent expense |  |  | $ 2,200 | $ 2,500

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- Definition Term of lessee's operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 50 -Paragraph 3 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=77888426&loc=SL77918673-209980 + Details
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- Definition Rental expense for the reporting period incurred under operating leases, including minimum and any contingent rent expense, net of related sublease income. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41499-112717 + Details
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