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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Components of Income/(Loss) Before Income Tax Provision (Benefit)

The components of income/(loss) before income tax provision (benefit) as of December 31, 2017 and 2016 are as follows (in thousands):

		2017			2016
U.S.	$	(21,915)		$	(20,387)
Foreign		(771)			(1,659)
	$	(22,686)		$	(22,046)

Reconciliation of Total Income Tax Provision

A reconciliation of the total income tax provision tax rate to the statutory federal income tax rate of 34% for the years ended December 31, 2017 and 2016 is as follows:

		2017				2016
Income tax expense (benefit) at federal statutory rate			(34.0	)%			(34.0	)%
Income tax expense (benefit) at state statutory rate			(3.9	)%			(3.4	)%
Change in valuation allowance			(172.4	)%			16.8	%
Change in state rate			(0.8	)%			(0.1	)%
Permanent interest adjustments			0.2	%			0.2	%
Stock compensation			3.0	%			12.7	%
Research credit			(1.1	)%			(1.4	)%
Foreign rate differential			202.1	%			0.8	%
NOLs expiring and adjustments to NOL			7.0	%			6.0	%
Other, net			(0.2	)%			2.5	%
			(0.0	)%			0.0	%

Deferred Tax Assets and Liabilities

The tax effects of temporary differences that give rise to significant portions of our deferred tax assets and deferred tax liabilities as of December 31, 2017 and 2016 are as follows (in thousands):

		2017				2016
Deferred tax assets:
Allowances and reserves		$	140			$	573
Accrued expenses			154				701
Stock based compensation			1,065				1,947
Net operating loss carryforwards			87,426				125,182
Income tax credit carryforwards			8,587				7,764
Property and equipment, principally due to differences in    depreciation			514				675
Other, net			45				48
			97,931				136,890
Valuation allowance			(97,089	)			(134,873	)
Total deferred tax assets, net of allowance			842				2,017
Deferred tax liabilities:
Intangibles assets			(842	)			(2,017	)
Total deferred tax liability			(842	)			(2,017	)
Net deferred tax assets (liability)		$	—			$	—

Unrecognized Tax Benefits Activity

Following is a tabular reconciliation of the unrecognized tax benefits activity during the years ended December 31, 2017 and 2016 (in thousands):

		2017				2016
Unrecognized Tax Benefits – Beginning		$	2,062			$	1,987
Gross increases – tax positions in prior period			—				1
Gross decreases – tax positions in prior period			—				(13	)
Gross increase – current-period tax positions			95				87
Unrecognized Tax Benefits – Ending		$	2,157			$	2,062

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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