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Organization and Operations - Additional Information (Details)
 3 Months Ended 12 Months Ended
Nov. 28, 2017
USD ($)
$ / shares
shares
Sep. 05, 2017
$ / shares
May 31, 2017
USD ($)
$ / shares
shares
Apr. 11, 2017
USD ($)
$ / shares
shares
Dec. 22, 2016
USD ($)
Jun. 16, 2016
USD ($)
shares
May 10, 2016
shares
Dec. 31, 2017
USD ($)
$ / shares
shares
Sep. 30, 2017
USD ($)
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
$ / shares
shares
Sep. 30, 2016
USD ($)
Jun. 30, 2016
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2017
USD ($)
Subsidiary
$ / shares
shares
Dec. 31, 2016
USD ($)
$ / shares
shares
Jun. 15, 2016
$ / shares
shares
May 11, 2016
shares
Dec. 31, 2015
USD ($)
shares
Basis Of Presentation And New Accounting Standards [Line Items]                                        
Number of wholly-owned subsidiaries | Subsidiary                               5        
Reverse stock split of common stock             15                          
Common stock, shares outstanding (in shares)             200,000,000 57,825,729       21,707,890       57,825,729 21,707,890   13,300,000  
Number of shares callable by warrants (in shares)             16,000,000                     1 1,100,000  
Common stock, shares authorized (in shares)             290,000,000 75,000,000       75,000,000       75,000,000 75,000,000   75,000,000  
Net loss | $               $ 4,286,000 $ 4,807,000 $ 6,049,000 $ 7,544,000 $ 4,918,000 $ 5,384,000 $ 6,405,000 $ 5,339,000 $ 22,686,000 $ 22,046,000      
Accumulated deficit | $               (401,749,000)       (379,063,000)       (401,749,000) (379,063,000)      
Net cash used in operating activities | $                               $ (18,128,000) (19,533,000)      
Substantial doubt about going concern, description                               The Company does not have sufficient capital to fund operations through one year from the issuance date of these consolidated financial statements. These factors raise substantial doubt about the Company’s ability to continue as a going concern.        
Cash and cash equivalents | $               9,550,000       $ 12,560,000       $ 9,550,000 12,560,000     $ 14,338,000
Minimum cash/cash equivalents covenant | $               $ 1,500,000               1,500,000        
Common stock issued (in shares) 10,000         6,704,852                            
Each unit consist of number of warrant           3,352,306                            
Warrant exercise price (in dollars per share) | $ / shares                                   $ 3.06    
Proceeds from issuance warrants | $ $ 8,800,000         $ 17,100,000                            
Common stock issued, value | $                               $ 12,716,000 $ 19,478,000      
Common stock, par value (in dollars per share) | $ / shares               $ 0.001       $ 0.001       $ 0.001 $ 0.001      
Proceeds from sale of common stock, net | $                               $ 23,613,000 $ 21,467,000      
Series B Convertible Preferred Stock [Member]                                        
Basis Of Presentation And New Accounting Standards [Line Items]                                        
Number of shares callable by warrants (in shares) 18,000,000                                      
Common stock issued (in shares) 30,000,000                                      
Common stock issued, value | $                               $ 8,767,000        
Nasdaq Stock Market LLC [Member]                                        
Basis Of Presentation And New Accounting Standards [Line Items]                                        
Number of consecutive business days no longer able to meet the required closing bid price of common stock   30 days                                    
Minimum bid price of common stock required for Nasdaq listing rule | $ / shares   $ 1                                    
Grace period provided with minimum bid price for Nasdaq listing rule   180 days                                    
Grace date for minimum bid price requirement for Nasdaq listing   Mar. 05, 2018                                    
Common stock minimum bid price required to regain compliance | $ / shares   $ 1                                    
Number of consecutive business days required to regain compliance   10 days                                    
Additional grace period provided with minimum bid price to regain compliance   180 days                                    
Date to regain compliance after meeting continued listing requirement   Sep. 04, 2018                                    
Common Stock [Member]                                        
Basis Of Presentation And New Accounting Standards [Line Items]                                        
Common stock, shares outstanding (in shares)               57,825,729       21,707,890       57,825,729 21,707,890     13,003,893
Number of shares callable by warrants (in shares)               1               1        
Common stock issued (in shares) 10,000         6,704,852                   12,237,079 8,673,253      
Each unit consist of number of warrant                               0.5        
Warrant exercise price (in dollars per share) | $ / shares $ 0.3333             $ 3.06               $ 3.06        
Common stock issued, value | $                               $ 12,000 $ 9,000      
Period exercisable from the date of issuance                               30 months        
Share issued, price per share | $ / shares       $ 1.10                                
Common Stock [Member] | Maxim Group LLC [Member]                                        
Basis Of Presentation And New Accounting Standards [Line Items]                                        
Common stock issued (in shares)     849,000 8,600,000                                
Common stock, par value (in dollars per share) | $ / shares       $ 0.001                                
Share issued, price per share | $ / shares     $ 1.10 $ 1.0395                                
Proceeds from sale of common stock, net | $     $ 800,000 $ 8,700,000                                
Closing of offering date       Apr. 17, 2017                                
Number of days granted as option to purchase additional shares of common stock to underwriter       45 days                                
Additional shares of common stock       944,000                                
Common Stock [Member] | Lincoln Park Capital Fund, LLC [Member]                                        
Basis Of Presentation And New Accounting Standards [Line Items]                                        
Common stock issued, value | $         $ 20,000,000                              
Period exercisable from the date of issuance         30 months                              
Minimum [Member]                                        
Basis Of Presentation And New Accounting Standards [Line Items]                                        
Unrestricted cash and cash equivalents | $               $ 1,500,000               $ 1,500,000        
2014 Equity Incentive Plan [Member]                                        
Basis Of Presentation And New Accounting Standards [Line Items]                                        
Number of shares callable by warrants (in shares)             6,500,000                       400,000