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Commitments and Contingencies (Details) - USD ($)
$ in Thousands
12 Months Ended
Feb. 27, 2017
Jan. 27, 2017
Dec. 31, 2017
Dec. 31, 2016
Recorded Unconditional Purchase Obligation [Line Items]        
Contractual obligation, due in next twelve months     $ 5,192  
Initial term of lease 63 months      
Lease commencement date Jan. 01, 2018      
Buy-out of obligations lease $ 600      
Japan Lease [Member]        
Recorded Unconditional Purchase Obligation [Line Items]        
Initial term of lease   61 months    
Lease commencement date     Apr. 15, 2017  
Pre-clinical Research Study Obligations [Member]        
Recorded Unconditional Purchase Obligation [Line Items]        
Contractual obligation, due in next twelve months     $ 600  
Operating Lease Obligations [Member]        
Recorded Unconditional Purchase Obligation [Line Items]        
Rent expense     $ 2,200 $ 2,500