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Quarterly Information (unaudited) (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016
Quarterly Financial Information Disclosure [Line Items]
Product revenues	$ 662	$ 467	$ 969	$ 591	$ 1,466	$ 731	$ 1,126	$ 1,333	$ 2,689	$ 4,656
Gross profit	29	(20)	262	(125)	521	113	541	766	146	1,941
Development revenues	867	1,306	531	1,018	1,561	1,879	1,699	1,585
Operating expenses	(4,526)	(5,629)	(6,374)	(6,336)	(5,670)	(6,789)	(8,464)	(7,448)
Other expense, net	(656)	(464)	(468)	(415)	(1,330)	(587)	(181)	(242)	(2,003)	(2,340)
Net loss	(4,286)	(4,807)	(6,049)	(7,544)	(4,918)	(5,384)	(6,405)	(5,339)	(22,686)	(22,046)
Beneficial conversion feature for convertible preferred stock	(3,977)	0	0	0	0	0	0	0	(3,977)	0
Net loss allocable to common stockholders	$ (8,263)	$ (4,807)	$ (6,049)	$ (7,544)	$ (4,918)	$ (5,384)	$ (6,405)	$ (5,339)	$ (26,663)	$ (22,046)
Basic and diluted net loss per share	$ (0.20)	$ (0.14)	$ (0.19)	$ (0.33)	$ (0.24)	$ (0.26)	$ (0.43)	$ (0.41)	$ (0.82)	$ (1.28)
Azaya Therapeutics, Inc. [Member]
Quarterly Financial Information Disclosure [Line Items]
In process research and development acquired from Azaya				$ (1,686)					$ (1,686)	$ 0

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