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Liquidity (Details) - USD ($)
 3 Months Ended
Nov. 28, 2017
Sep. 05, 2017
May 31, 2017
Apr. 11, 2017
Dec. 22, 2016
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Liquidity [Line Items]                
Net loss           $ 4,409,000 $ 7,544,000  
Accumulated deficit           406,158,000   $ 401,749,000
Net cash used in operating activities           4,119,000 4,827,000  
Cash and cash equivalents           5,902,000   $ 9,550,000
Minimum cash/cash equivalents covenant           $ 1,500,000    
Common stock issued (in shares) 10,000              
Common stock, par value (in dollars per share)           $ 0.001   $ 0.001
Proceeds from sale of common stock, net           $ (150,000) $ 1,435,000  
Proceeds from issuance warrants $ 8,800,000              
Series B Convertible Preferred Stock [Member]                
Liquidity [Line Items]                
Common stock issued (in shares) 30,000,000              
Number of shares callable by warrants (in shares) 18,000,000              
Nasdaq Stock Market LLC [Member]                
Liquidity [Line Items]                
Number of consecutive business days no longer able to meet the required closing bid price of common stock   30 days            
Minimum bid price of common stock required for Nasdaq listing rule   $ 1            
Grace period provided with minimum bid price for Nasdaq listing rule   180 days            
Grace date for minimum bid price requirement for Nasdaq listing   Mar. 05, 2018            
Common stock minimum bid price required to regain compliance   $ 1            
Number of consecutive business days required to regain compliance   10 days            
Additional grace period provided with minimum bid price to regain compliance   180 days            
Date to regain compliance after meeting continued listing requirement   Sep. 04, 2018            
Common Stock [Member]                
Liquidity [Line Items]                
Common stock issued (in shares) 10,000              
Share issued, price per share       $ 1.10        
Number of shares callable by warrants (in shares)           1    
Warrant exercise price (in dollars per share) $ 0.3333              
Common Stock [Member] | Maxim Group LLC [Member]                
Liquidity [Line Items]                
Common stock issued (in shares)     849,000 8,600,000        
Common stock, par value (in dollars per share)       $ 0.001        
Share issued, price per share     $ 1.10 $ 1.0395        
Proceeds from sale of common stock, net     $ 800,000 $ 8,700,000        
Closing of offering date       Apr. 17, 2017        
Number of days granted as option to purchase additional shares of common stock to underwriter       45 days        
Additional shares of common stock       944,000        
Common Stock [Member] | Lincoln Park Capital Fund, LLC [Member]                
Liquidity [Line Items]                
Common stock issued, value         $ 20,000,000      
Period exercisable from the date of issuance         30 months      
Minimum [Member]                
Liquidity [Line Items]                
Unrestricted cash and cash equivalents           $ 1,500,000