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Liquidity (Details) - USD ($) |  |  |  |  |  |  | 3 Months Ended | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jul. 25, 2018 | Nov. 28, 2017 | Sep. 05, 2017 | May 31, 2017 | Apr. 11, 2017 | Dec. 22, 2016 | Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017 | May 24, 2018 | May 23, 2018 | Dec. 31, 2017
Liquidity [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  |  |  |  |  | $ 3,659,000 | $ 6,049,000 | $ 8,068,000 | $ 13,593,000 |  |  |
Accumulated deficit |  |  |  |  |  |  | 409,817,000 |  | 409,817,000 |  |  |  | $ 401,749,000
Net cash used in operating activities |  |  |  |  |  |  |  |  | 6,840,000 | 9,855,000 |  |  |
Cash and cash equivalents |  |  |  |  |  |  | 3,079,000 |  | 3,079,000 |  |  |  | $ 9,550,000
Minimum cash/cash equivalents covenant |  |  |  |  |  |  | $ 1,500,000 |  | $ 1,500,000 |  |  |  |
Common stock issued (in shares) | 6,723 | 10,000 |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) |  |  |  |  |  |  | $ 0.001 |  | $ 0.001 |  |  | $ 0.001 | $ 0.001
Proceeds from sale of common stock, net |  |  |  |  |  |  |  |  | $ (200,000) | $ 11,225,000 |  |  |
Number of shares callable by warrants (in shares) |  |  |  |  |  |  |  |  |  |  | 2,300,000 | 23,400,000 |
Proceeds from issuance warrants | $ 5,700,000 | $ 8,800,000 |  |  |  |  |  |  |  |  |  |  |
Series B Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Liquidity [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued (in shares) |  | 3,000,000 |  |  |  |  |  |  |  |  |  |  |
Number of shares callable by warrants (in shares) |  | 18,000,000 |  |  |  |  |  |  |  |  |  |  |
Series C Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Liquidity [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued (in shares) | 8,400,000 |  |  |  |  |  |  |  |  |  |  |  |
Number of shares callable by warrants (in shares) | 7,059,150 |  |  |  |  |  |  |  |  |  |  |  |
Nasdaq Stock Market LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Liquidity [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of consecutive business days no longer able to meet the required closing bid price of common stock |  |  | 30 days |  |  |  |  |  |  |  |  |  |
Minimum bid price of common stock required for Nasdaq listing rule |  |  | $ 1 |  |  |  |  |  |  |  |  |  |
Grace period provided with minimum bid price for Nasdaq listing rule |  |  | 180 days |  |  |  |  |  |  |  |  |  |
Grace date for minimum bid price requirement for Nasdaq listing |  |  | Mar. 05, 2018 |  |  |  |  |  |  |  |  |  |
Common stock minimum bid price required to regain compliance |  |  | $ 1 |  |  |  |  |  |  |  |  |  |
Number of consecutive business days required to regain compliance |  |  | 10 days |  |  |  |  |  |  |  |  |  |
Additional grace period provided with minimum bid price to regain compliance |  |  | 180 days |  |  |  |  |  |  |  |  |  |
Date to regain compliance after meeting continued listing requirement |  |  | Sep. 04, 2018 |  |  |  |  |  |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Liquidity [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued (in shares) | 6,723 | 10,000 |  |  |  |  |  |  |  |  |  |  |
Share issued, price per share |  |  |  |  | $ 11.00 |  |  |  |  |  |  |  |
Number of shares callable by warrants (in shares) | 1 | 1,800,000 |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) | $ 0.7986 | $ 3.333 |  |  |  |  |  |  |  |  |  |  |
Common Stock [Member] | Maxim Group LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Liquidity [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued (in shares) |  |  |  | 84,900 | 900,000 |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) |  |  |  |  | $ 0.001 |  |  |  |  |  |  |  |
Share issued, price per share |  |  |  | $ 11.00 | $ 10.40 |  |  |  |  |  |  |  |
Proceeds from sale of common stock, net |  |  |  | $ 800,000 | $ 8,700,000 |  |  |  |  |  |  |  |
Closing of offering date |  |  |  |  | Apr. 17, 2017 |  |  |  |  |  |  |  |
Number of days granted as option to purchase additional shares of common stock to underwriter |  |  |  |  | 45 days |  |  |  |  |  |  |  |
Additional shares of common stock |  |  |  |  | 94,400 |  |  |  |  |  |  |  |
Common Stock [Member] | Lincoln Park Capital Fund, LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Liquidity [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, value |  |  |  |  |  | $ 20,000,000 |  |  |  |  |  |  |
Period exercisable from the date of issuance |  |  |  |  |  | 30 months |  |  |  |  |  |  |
Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Liquidity [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Unrestricted cash and cash equivalents |  |  |  |  |  |  | $ 1,500,000 |  | $ 1,500,000 |  |  |  |

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