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Liquidity (Details) - USD ($)
 3 Months Ended 6 Months Ended
Jul. 25, 2018
Nov. 28, 2017
Sep. 05, 2017
May 31, 2017
Apr. 11, 2017
Dec. 22, 2016
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
May 24, 2018
May 23, 2018
Dec. 31, 2017
Liquidity [Line Items]                          
Net loss             $ 3,659,000 $ 6,049,000 $ 8,068,000 $ 13,593,000      
Accumulated deficit             409,817,000   409,817,000       $ 401,749,000
Net cash used in operating activities                 6,840,000 9,855,000      
Cash and cash equivalents             3,079,000   3,079,000       $ 9,550,000
Minimum cash/cash equivalents covenant             $ 1,500,000   $ 1,500,000        
Common stock issued (in shares) 6,723 10,000                      
Common stock, par value (in dollars per share)             $ 0.001   $ 0.001     $ 0.001 $ 0.001
Proceeds from sale of common stock, net                 $ (200,000) $ 11,225,000      
Number of shares callable by warrants (in shares)                     2,300,000 23,400,000  
Proceeds from issuance warrants $ 5,700,000 $ 8,800,000                      
Series B Convertible Preferred Stock [Member]                          
Liquidity [Line Items]                          
Common stock issued (in shares)   3,000,000                      
Number of shares callable by warrants (in shares)   18,000,000                      
Series C Convertible Preferred Stock [Member]                          
Liquidity [Line Items]                          
Common stock issued (in shares) 8,400,000                        
Number of shares callable by warrants (in shares) 7,059,150                        
Nasdaq Stock Market LLC [Member]                          
Liquidity [Line Items]                          
Number of consecutive business days no longer able to meet the required closing bid price of common stock     30 days                    
Minimum bid price of common stock required for Nasdaq listing rule     $ 1                    
Grace period provided with minimum bid price for Nasdaq listing rule     180 days                    
Grace date for minimum bid price requirement for Nasdaq listing     Mar. 05, 2018                    
Common stock minimum bid price required to regain compliance     $ 1                    
Number of consecutive business days required to regain compliance     10 days                    
Additional grace period provided with minimum bid price to regain compliance     180 days                    
Date to regain compliance after meeting continued listing requirement     Sep. 04, 2018                    
Common Stock [Member]                          
Liquidity [Line Items]                          
Common stock issued (in shares) 6,723 10,000                      
Share issued, price per share         $ 11.00                
Number of shares callable by warrants (in shares) 1 1,800,000                      
Warrant exercise price (in dollars per share) $ 0.7986 $ 3.333                      
Common Stock [Member] | Maxim Group LLC [Member]                          
Liquidity [Line Items]                          
Common stock issued (in shares)       84,900 900,000                
Common stock, par value (in dollars per share)         $ 0.001                
Share issued, price per share       $ 11.00 $ 10.40                
Proceeds from sale of common stock, net       $ 800,000 $ 8,700,000                
Closing of offering date         Apr. 17, 2017                
Number of days granted as option to purchase additional shares of common stock to underwriter         45 days                
Additional shares of common stock         94,400                
Common Stock [Member] | Lincoln Park Capital Fund, LLC [Member]                          
Liquidity [Line Items]                          
Common stock issued, value           $ 20,000,000              
Period exercisable from the date of issuance           30 months              
Minimum [Member]                          
Liquidity [Line Items]                          
Unrestricted cash and cash equivalents             $ 1,500,000   $ 1,500,000