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Liquidity (Details) - USD ($)
 3 Months Ended 4 Months Ended 9 Months Ended
Sep. 21, 2018
Aug. 31, 2018
Aug. 28, 2018
Jul. 25, 2018
Jun. 01, 2018
Nov. 28, 2017
Sep. 05, 2017
May 31, 2017
Apr. 11, 2017
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2018
Sep. 30, 2017
May 24, 2018
May 23, 2018
Dec. 31, 2017
Liquidity [Line Items]                                  
Net loss                   $ 2,330,000 $ 4,807,000   $ 10,398,000 $ 18,399,000      
Accumulated deficit                   412,147,000   $ 412,147,000 412,147,000       $ 401,749,000
Net cash used in operating activities                         9,487,000 $ 13,904,000      
Aggregate pincipal payments   $ 7,000,000                              
Cash and cash equivalents                   6,806,000   6,806,000 6,806,000       $ 9,550,000
Minimum cash/cash equivalents covenant                   1,500,000   $ 1,500,000 $ 1,500,000        
Common stock issued (in shares)       6,723   10,000                      
Number of shares callable by warrants (in shares)                             2,300,000 23,400,000  
Proceeds from issuance warrants       $ 5,700,000   $ 8,800,000                      
Series B Convertible Preferred Stock [Member]                                  
Liquidity [Line Items]                                  
Common stock issued (in shares)           3,000,000                      
Number of shares callable by warrants (in shares)           18,000,000                      
Series C Convertible Preferred Stock [Member]                                  
Liquidity [Line Items]                                  
Number of shares callable by warrants (in shares)       7,059,150                          
Number of convertible shares converted into common stock (in shares)       8,400,000                          
Nasdaq Stock Market LLC [Member]                                  
Liquidity [Line Items]                                  
Number of consecutive business days no longer able to meet the required closing bid price of common stock     30 days       30 days                    
Minimum bid price of common stock required for Nasdaq listing rule     $ 1       $ 1                    
Grace period provided with minimum bid price for Nasdaq listing rule     180 days       180 days                    
Grace date for minimum bid price requirement for Nasdaq listing     Feb. 25, 2019       Mar. 05, 2018                    
Common stock minimum bid price required to regain compliance     $ 1       $ 1                    
Number of consecutive business days required to regain compliance     10 days       10 days                    
Additional grace period provided with minimum bid price to regain compliance     180 days       180 days                    
Description of compliance with minimum bid price requirement                         In the event we do not regain compliance within this 180-day period, we may be eligible to seek an additional compliance period of 180 calendar days if we meet the continued listing requirement for market value of publicly held shares and all other initial listing standards for the Nasdaq Capital Market, with the exception of the bid price requirement, if we provide written notice to Nasdaq of our intent to cure the deficiency during this second compliance period, by effecting a reverse stock split, if necessary        
Common Stock [Member]                                  
Liquidity [Line Items]                                  
Common stock issued (in shares)       6,723   10,000                      
Share issued, price per share                 $ 11.00                
Number of shares callable by warrants (in shares)       1   1,800,000                      
Warrant exercise price (in dollars per share)       $ 0.7986   $ 3.333                      
Common Stock [Member] | Lincoln Park [Member]                                  
Liquidity [Line Items]                                  
Common stock issued, value $ 5,000,000                                
Period exercisable from the date of issuance 24 months                                
Common Stock [Member] | Maxim Group LLC [Member]                                  
Liquidity [Line Items]                                  
Common stock issued (in shares)               84,900 900,000                
Share issued, price per share               $ 11.00 $ 10.40                
Proceeds from sale of common stock, net               $ 800,000 $ 8,700,000                
Closing of offering date                 Apr. 17, 2017                
Number of days granted as option to purchase additional shares of common stock to underwriter                 45 days                
Additional shares of common stock                 94,400                
Common Stock [Member] | ATM Program [Member] | B. Riley FBR [Member] | Sales Agreement [Member]                                  
Liquidity [Line Items]                                  
Common stock issued (in shares)                       1,500,000          
Proceeds from sale of common stock, net                       $ 800,000          
Minimum [Member]                                  
Liquidity [Line Items]                                  
Unrestricted cash and cash equivalents                   $ 1,500,000   $ 1,500,000 $ 1,500,000        
Maximum [Member] | Common Stock [Member] | ATM Program [Member] | B. Riley FBR [Member] | Sales Agreement [Member]                                  
Liquidity [Line Items]                                  
Proceeds from sale of common stock, net         $ 6,500,000