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Term Loan Obligations (Details) - USD ($)
 3 Months Ended 9 Months Ended
Aug. 31, 2018
Jun. 19, 2018
Dec. 29, 2017
May 29, 2015
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
May 24, 2018
May 23, 2018
Sep. 20, 2017
Debt Instrument [Line Items]                      
Number of shares callable by warrants (in shares)                 2,300,000 23,400,000  
Minimum liquidity covenant         $ 1,500,000   $ 1,500,000        
Minimum amount to be paid pursuant prepayment requirement $ 7,000,000                    
Interest expense         512,000 $ 474,000 1,379,000 $ 1,603,000      
Non-cash amortization         200,000 $ 200,000 $ 400,000 $ 600,000      
LIBOR [Member] | Interest Rate Floor [Member]                      
Debt Instrument [Line Items]                      
Basis variable rate       1.00%              
Term Loan [Member]                      
Debt Instrument [Line Items]                      
Origination Date             May 29, 2015        
Original Loan Amount       $ 17,700,000              
Basis variable rate       7.95%              
Maturity date             Jun. 01, 2019        
Fees amount associated with loan       $ 1,100,000              
Number of shares callable by warrants (in shares)       9,444              
Warrant exercise price (in dollars per share)       $ 103.50              
Date from which warrants are exercisable             Nov. 30, 2015        
Warrant expiration date             May 29, 2025        
Minimum liquidity covenant       $ 5,000,000             $ 1,500,000
Extended interest-only period Dec. 31, 2018 Dec. 01, 2018         Aug. 01, 2018        
Debt instrument, interest-only period The Third Amendment extends the interest-only period under the Term Loan to December 31, 2018 and also requires that the Company pay to Oxford, in accordance with its pro rata share of the loans, 75% of all proceeds received (i) from the issuance and sale of unsecured subordinated convertible debt, (ii) in connection with a joint venture, collaboration or other partnering transaction, (iii) in connection with any licenses, (iv) from dividends (other than non-cash dividends from wholly owned subsidiaries) and (v) from the sale of any assets (such requirement, the “Prepayment Requirement”). The Second Amendment extends the interest-only period under the Term Loan to December 1, 2018 if the Company receives unrestricted gross cash proceeds of at least $15 million from the sale and issuance of the Company’s equity securities on or before August 31, 2018.         The amendment also extended the interest-only period under the Loan Agreement through August 1, 2018, as the Company successfully closed on a financing and received unrestricted net cash proceeds in excess of $5 million on or before December 29, 2017.        
Net proceeds excess receives from unrestricted cash     $ 5,000,000                
Amendment fee $ 50,000 $ 250,000                  
Percentage of proceeds received 75.00%                    
Minimum amount to be paid pursuant prepayment requirement $ 7,000,000                    
Debt instrument prepayment, description The Prepayment Requirement does not apply to proceeds from the sale and issuance of the Company’s equity securities, other than convertible debt. The Prepayment Requirement shall apply until an aggregate principle amount of $7.0 million has been paid pursuant to the Prepayment Requirement. However, if less than $7.0 million has been paid pursuant to the Prepayment Requirement on December 31, 2018 then the Company is required to promptly make additional payments until an aggregate principal amount of $7.0 million has been paid.                    
Debt instrument, covenant compliance             we were in compliance with all of the debt covenants under the Loan and Security Agreement.        
Minimum [Member] | Term Loan [Member]                      
Debt Instrument [Line Items]                      
Interest rate       8.95%              
Unrestricted gross cash proceeds required to extend interest-only period   $ 15,000,000                  
Maximum [Member] | Term Loan [Member]                      
Debt Instrument [Line Items]                      
Original Loan Amount         $ 3,000,000   $ 3,000,000