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Income Taxes - Reconciliation of Total Income Tax Provision (Details) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Reconciliation of the total income tax provision tax rate [Abstract] |  |
Income tax expense (benefit) at federal statutory rate | (21.00%) | (34.00%)
Income tax expense (benefit) at state statutory rate | (5.80%) | (3.90%)
Change in valuation allowance | 31.80% | (172.40%)
Change in state rate | (0.10%) | (0.80%)
Permanent interest adjustments | 0.50% | 0.20%
Stock compensation | 1.30% | 3.00%
Research credit | (1.00%) | (1.10%)
Foreign rate differential |  | 202.10%
NOLs expiring and adjustments to NOL |  | 7.00%
Mark to market adjustment | (3.70%) |
Other, net | (2.00%) | (0.10%)
Total income tax provision | 0.00% | 0.00%

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