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Organization and Operations - Additional Information (Details)
 3 Months Ended 7 Months Ended 12 Months Ended
Sep. 21, 2018
USD ($)
Aug. 28, 2018
$ / shares
Jul. 25, 2018
USD ($)
$ / shares
shares
Jun. 01, 2018
USD ($)
May 23, 2018
$ / shares
shares
Nov. 28, 2017
USD ($)
$ / shares
shares
Sep. 05, 2017
$ / shares
May 31, 2017
USD ($)
$ / shares
shares
Apr. 11, 2017
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
Subsidiary
$ / shares
shares
Dec. 31, 2017
USD ($)
$ / shares
shares
May 24, 2018
shares
Nov. 27, 2017
shares
Dec. 31, 2016
USD ($)
shares
Basis Of Presentation And New Accounting Standards [Line Items]                                
Number of wholly-owned subsidiaries | Subsidiary                       5        
Reverse stock split of common stock         0.1                      
Common stock, par value (in dollars per share) | $ / shares         $ 0.001         $ 0.001 $ 0.001 $ 0.001 $ 0.001      
Common stock, shares authorized (in shares)         75,000,000         100,000,000 100,000,000 100,000,000 100,000,000 100,000,000    
Common stock, shares issued (in shares)         61,600,000         14,830,414 14,830,414 14,830,414 14,830,414 6,200,000    
Common stock, shares outstanding (in shares)         61,600,000         5,782,573 5,782,573 5,782,573 5,782,573 6,200,000    
Number of shares callable by warrants (in shares)         23,400,000                 2,300,000    
Preferred stock, shares authorized (in shares)         5,000,000         5,000,000 5,000,000 5,000,000 5,000,000 5,000,000    
Common stock, reverse stock split, fractional shares issued         0                      
Net loss | $                       $ 12,634,000 $ 22,686,000      
Accumulated deficit | $                   $ (414,383,000) $ (414,383,000) (414,383,000) (401,749,000)      
Net cash used in operating activities | $                       $ (11,975,000) (18,128,000)      
Substantial doubt about going concern, description                       These factors raise substantial doubt about the Company’s ability to continue as a going concern.        
Net proceeds excess receives from unrestricted cash | $                       $ 4,000,000        
Cash and cash equivalents | $                   5,261,000 5,261,000 5,261,000 9,550,000     $ 12,600,000
Minimum cash/cash equivalents covenant | $                   $ 2,000,000 $ 2,000,000 2,000,000        
Common stock issued (in shares)     6,723     10,000                    
Proceeds from issuance warrants | $     $ 5,700,000     $ 8,800,000                    
Date from which warrants are exercisable           May 18, 2018                    
Common stock issued, value | $                       1,624,000 12,716,000      
Series B Convertible Preferred Stock [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Number of shares callable by warrants (in shares)           18,000,000                    
Preferred stock, shares authorized (in shares)                             10,000  
Common stock issued (in shares)           3,000,000                    
Common stock issued, value | $                         $ 8,767,000      
Series C Convertible Preferred Stock [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Number of shares callable by warrants (in shares)     7,059,150                          
Preferred stock, shares authorized (in shares)     7,000                          
Number of convertible shares converted into common stock (in shares)     8,400,000                          
Common stock issued, value | $                       $ 3,041,000        
Nasdaq Stock Market LLC [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Number of consecutive business days no longer able to meet the required closing bid price of common stock   30 days         30 days                  
Minimum bid price of common stock required for Nasdaq listing rule | $ / shares   $ 1.00         $ 1.00                  
Grace period provided with minimum bid price for Nasdaq listing rule   180 days         180 days                  
Grace date for minimum bid price requirement for Nasdaq listing   Feb. 25, 2019         Mar. 05, 2018                  
Common stock minimum bid price required to regain compliance | $ / shares   $ 1.00         $ 1.00                  
Number of consecutive business days required to regain compliance   10 days         10 days                  
Additional grace period provided with minimum bid price to regain compliance   180 days         180 days                  
Date to regain compliance after meeting continued listing requirement   Aug. 26, 2019         Sep. 04, 2018                  
Description of compliance with minimum bid price requirement                       We were granted an additional compliance period of 180 calendar days, or until August 26, 2019, in which to regain compliance after meeting the continued listing requirement for market value of publicly held shares and all other initial listing standards for the Nasdaq Capital Market, with the exception of the bid price requirement, and providing notice to Nasdaq staff of our intent to cure the deficiency during this second compliance period, by effecting a reverse stock split, if necessary.        
Common Stock [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Common stock, shares outstanding (in shares)                   14,830,414 14,830,414 14,830,414 5,782,573     2,170,789
Number of shares callable by warrants (in shares)     1     1,800,000                    
Common stock issued (in shares)     6,723     10,000           4,608,453 1,223,708      
Share issued, price per share | $ / shares                 $ 11.00              
Warrant exercise price (in dollars per share) | $ / shares     $ 0.7986     $ 3.333                    
Common stock issued, value | $                       $ 5,000 $ 1,000      
Common Stock [Member] | B. Riley FBR [Member] | Sales Agreement [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Common stock issued (in shares)                     3,900,000          
Proceeds from sale of common stock, net | $                     $ 1,700,000          
Common Stock [Member] | Lincoln Park [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Proceeds from sale of common stock, net | $                   $ 300,000            
Common stock issued, value | $ $ 5,000,000                 600,000            
Period exercisable from the date of issuance 24 months                              
Common Stock [Member] | Series B Convertible Preferred Stock [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Number of convertible shares converted into common stock (in shares)                       396,045 2,270,632      
Common Stock [Member] | Series C Convertible Preferred Stock [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Number of convertible shares converted into common stock (in shares)                       4,043,343        
Common Stock [Member] | Maxim Group LLC [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Common stock issued (in shares)               84,900 900,000              
Share issued, price per share | $ / shares               $ 11.00 $ 10.40              
Proceeds from sale of common stock, net | $               $ 800,000 $ 8,700,000              
Closing of offering date                 Apr. 17, 2017              
Number of days granted as option to purchase additional shares of common stock to underwriter                 45 days              
Additional shares of common stock                 94,400              
Minimum [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Unrestricted cash and cash equivalents | $                   $ 2,000,000 $ 2,000,000 $ 2,000,000        
Maximum [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Unrestricted gross cash proceeds required to extend interest-only period | $                       $ 7,500,000        
Maximum [Member] | Common Stock [Member] | B. Riley FBR [Member] | Sales Agreement [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Proceeds from sale of common stock, net | $       $ 6,500,000                        
2014 Equity Incentive Plan [Member]                                
Basis Of Presentation And New Accounting Standards [Line Items]                                
Number of shares callable by warrants (in shares)         9,100,000                 900,000