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Term Loan Obligations (Details) - USD ($)
 3 Months Ended
Dec. 31, 2018
Aug. 31, 2018
Jun. 19, 2018
Dec. 29, 2017
May 29, 2015
Mar. 31, 2019
Mar. 31, 2018
May 24, 2018
May 23, 2018
Sep. 20, 2017
Debt Instrument [Line Items]                    
Number of shares callable by warrants (in shares)               2,300,000 23,400,000  
Minimum liquidity covenant           $ 2,000,000        
Interest expense           515,000 $ 423,000      
Non-cash amortization           $ 200,000 $ 100,000      
LIBOR [Member] | Interest Rate Floor [Member]                    
Debt Instrument [Line Items]                    
Basis variable rate         1.00%          
Term Loan [Member]                    
Debt Instrument [Line Items]                    
Origination Date           May 29, 2015        
Original Loan Amount         $ 17,700,000          
Basis variable rate         7.95%          
Maturity date Jun. 01, 2019         Jun. 01, 2019        
Fees amount associated with loan         $ 1,100,000          
Number of shares callable by warrants (in shares)         9,444          
Warrant exercise price (in dollars per share)         $ 103.50          
Date from which warrants are exercisable           Nov. 30, 2015        
Warrant expiration date           May 29, 2025        
Minimum liquidity covenant $ 2,000,000       $ 5,000,000         $ 1,500,000
Extended interest-only period Jun. 01, 2020 Dec. 31, 2018 Dec. 01, 2018     Aug. 01, 2018        
Debt instrument, interest-only period The Fourth Amendment also required that the Company achieve one of the following by January 31, 2019: enter into an asset sale agreement with a minimum unrestricted net cash proceeds to the Company of $4.0 million; enter into a binding agreement for the issuance and sale of its equity securities or unsecured convertible subordinated debt which would result in unrestricted gross cash proceeds of not less than $7.5 million; or enter into a merger agreement pursuant to which the obligations under the Loan and Security Agreement would be paid down to a level satisfactory to Oxford The Third Amendment extends the interest-only period under the Term Loan to December 31, 2018 and also requires that the Company pay to Oxford, in accordance with its pro rata share of the loans, 75% of all proceeds received (i) from the issuance and sale of unsecured subordinated convertible debt, (ii) in connection with a joint venture, collaboration or other partnering transaction, (iii) in connection with any licenses, (iv) from dividends (other than non-cash dividends from wholly owned subsidiaries) and (v) from the sale of any assets (such requirement, the “Prepayment Requirement”). The Second Amendment extends the interest-only period under the Term Loan to December 1, 2018 if the Company receives unrestricted gross cash proceeds of at least $15 million from the sale and issuance of the Company’s equity securities on or before August 31, 2018.     The amendment also extended the interest-only period under the Loan and Security Agreement through August 1, 2018, as the Company successfully closed on a financing and received unrestricted net cash proceeds in excess of $5 million on or before December 29, 2017.        
Net proceeds excess receives from unrestricted cash       $ 5,000,000            
Amendment fee $ 350,000 $ 50,000 $ 250,000              
Percentage of proceeds received   75.00%                
Minimum amount to be paid pursuant prepayment requirement   $ 7,000,000                
Debt instrument prepayment, description   The Prepayment Requirement does not apply to proceeds from the sale and issuance of the Company’s equity securities, other than convertible debt. The Prepayment Requirement shall apply until an aggregate principle amount of $7.0 million has been paid pursuant to the Prepayment Requirement. However, if less than $7.0 million has been paid pursuant to the Prepayment Requirement on December 31, 2018 then the Company is required to promptly make additional payments until an aggregate principal amount of $7.0 million has been paid.                
Debt instrument, covenant compliance           we were in compliance with all of the debt covenants under the Loan and Security Agreement.        
Minimum [Member] | Term Loan [Member]                    
Debt Instrument [Line Items]                    
Interest rate         8.95%          
Net proceeds excess receives from unrestricted cash 4,000,000                  
Unrestricted gross cash proceeds required to extend interest-only period $ 7,500,000   $ 15,000,000              
Maximum [Member] | Term Loan [Member]                    
Debt Instrument [Line Items]                    
Original Loan Amount           $ 3,000,000