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Organization and Operations - Additional Information (Details)
 3 Months Ended 7 Months Ended 10 Months Ended 12 Months Ended
Aug. 05, 2019
$ / shares
shares
Apr. 25, 2019
USD ($)
Apr. 24, 2019
USD ($)
Sep. 21, 2018
USD ($)
Aug. 28, 2018
$ / shares
Jul. 25, 2018
USD ($)
$ / shares
shares
Jun. 01, 2018
USD ($)
May 23, 2018
$ / shares
shares
Nov. 28, 2017
USD ($)
$ / shares
shares
Sep. 05, 2017
$ / shares
May 31, 2017
USD ($)
$ / shares
shares
Apr. 11, 2017
USD ($)
$ / shares
shares
Mar. 31, 2019
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
$ / shares
shares
Mar. 31, 2018
USD ($)
shares
Dec. 31, 2018
USD ($)
$ / shares
shares
Mar. 31, 2019
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
Subsidiary
$ / shares
shares
Dec. 31, 2017
USD ($)
$ / shares
shares
May 24, 2018
shares
Nov. 27, 2017
shares
Dec. 31, 2016
USD ($)
shares
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Number of wholly-owned subsidiaries | Subsidiary                                   5        
Reverse stock split of common stock               0.1                            
Common stock, par value (in dollars per share) | $ / shares               $ 0.001         $ 0.001 $ 0.001   $ 0.001 $ 0.001 $ 0.001 $ 0.001      
Common stock, shares authorized (in shares)               75,000,000         100,000,000 100,000,000   100,000,000 100,000,000 100,000,000 100,000,000 100,000,000    
Common stock, shares issued (in shares)               61,600,000         438,116 296,609   296,609 438,116 296,609 115,651 6,200,000    
Common stock, shares outstanding (in shares)               61,600,000         438,116 296,609   296,609 438,116 296,609 115,651 6,200,000    
Number of shares callable by warrants (in shares)               23,400,000                       2,300,000    
Preferred stock, shares authorized (in shares)               5,000,000         5,000,000 5,000,000   5,000,000 5,000,000 5,000,000 5,000,000 5,000,000    
Common stock, reverse stock split, fractional shares issued               0                            
Net loss | $                         $ 3,150,000   $ 4,409,000     $ 12,634,000 $ 22,686,000      
Net loss from discountinued operations | $                         686,000   1,130,000     3,756,000 9,592,000      
Accumulated deficit | $                         (417,533,000) $ (414,383,000)   $ (414,383,000) $ (417,533,000) (414,383,000) (401,749,000)      
Net cash used in operating activities | $                         $ (3,270,000)   (4,119,000)     $ (11,975,000) (18,128,000)      
Substantial doubt about going concern, description                         These factors raise substantial doubt about the Company’s ability to continue as a going concern.         These factors raise substantial doubt about the Company’s ability to continue as a going concern        
Net proceeds excess receives from unrestricted cash | $                                   $ 4,000,000        
Cash and cash equivalents | $                         $ 3,872,000 5,261,000   5,261,000 3,872,000 5,261,000 9,550,000     $ 12,600,000
Minimum cash/cash equivalents covenant | $                         2,000,000 $ 2,000,000   $ 2,000,000 $ 2,000,000 2,000,000        
Common stock issued (in shares)           6,723     10,000                          
Proceeds from sale of common stock, net | $                         1,919,000   (150,000)     0 0      
Proceeds from issuance warrants | $           $ 5,700,000     $ 8,800,000                          
Date from which warrants are exercisable                 May 18, 2018                          
Common stock issued, value | $                         $ 1,873,000   $ 27,000     1,624,000 12,716,000      
Series B Convertible Preferred Stock [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Number of shares callable by warrants (in shares)                 360,000                          
Preferred stock, shares authorized (in shares)                                         10,000  
Common stock issued (in shares)                 60,000                          
Common stock issued, value | $                                     $ 8,767,000      
Series C Convertible Preferred Stock [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Number of shares callable by warrants (in shares)           7,059,150                                
Preferred stock, shares authorized (in shares)           7,000                                
Number of convertible shares converted into common stock (in shares)           168,478                                
Common stock issued, value | $                                   $ 3,041,000        
Nasdaq Stock Market LLC [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Number of consecutive business days no longer able to meet the required closing bid price of common stock         30 days         30 days                        
Minimum bid price of common stock required for Nasdaq listing rule | $ / shares         $ 1.00         $ 1.00                        
Grace period provided with minimum bid price for Nasdaq listing rule         180 days         180 days                        
Grace date for minimum bid price requirement for Nasdaq listing         Feb. 25, 2019         Mar. 05, 2018                        
Common stock minimum bid price required to regain compliance | $ / shares         $ 1.00         $ 1.00                        
Number of consecutive business days required to regain compliance         10 days         10 days                        
Additional grace period provided with minimum bid price to regain compliance         180 days         180 days                        
Date to regain compliance after meeting continued listing requirement         Aug. 26, 2019         Sep. 04, 2018                        
Description of compliance with minimum bid price requirement         We were granted an additional compliance period of 180 calendar days, or until August 26, 2019, in which to regain compliance after meeting the continued listing requirement for market value of publicly held shares and all other initial listing standards for the Nasdaq Capital Market, with the exception of the bid price requirement, and providing notice to Nasdaq staff of our intent to cure the deficiency during this second compliance period, by effecting a reverse stock split, if necessary.                         We were granted an additional compliance period of 180 calendar days, or until August 26, 2019, in which to regain compliance after meeting the continued listing requirement for market value of publicly held shares and all other initial listing standards for the Nasdaq Capital Market, with the exception of the bid price requirement, and providing notice to Nasdaq staff of our intent to cure the deficiency during this second compliance period, by effecting a reverse stock split, if necessary.        
Common Stock [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Common stock, shares outstanding (in shares)                         438,116 296,609 123,227 296,609 438,116 296,609 115,651     43,416
Number of shares callable by warrants (in shares)           50     36,000                          
Common stock issued (in shares)           6,723     10,000       139,855   201     92,169 24,474      
Share issued, price per share | $ / shares                       $ 550.00                    
Warrant exercise price (in dollars per share) | $ / shares           $ 39.93     $ 166.65                          
Common Stock [Member] | B. Riley FBR [Member] | Sales Agreement [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Common stock issued (in shares)                               1,584 200,000          
Proceeds from sale of common stock, net | $                               $ 1,700,000 $ 3,800,000          
Common Stock [Member] | Lincoln Park [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Common stock issued (in shares)                         0 12,802                
Proceeds from sale of common stock, net | $                           $ 300,000                
Common stock issued, value | $       $ 5,000,000                                    
Period exercisable from the date of issuance       24 months                                    
Common Stock [Member] | Series B Convertible Preferred Stock [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Number of convertible shares converted into common stock (in shares)                             7,375     7,921 45,413      
Common Stock [Member] | Series C Convertible Preferred Stock [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Number of convertible shares converted into common stock (in shares)                         1,652         80,868        
Common Stock [Member] | Maxim Group LLC [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Common stock issued (in shares)                     1,698 17,881                    
Share issued, price per share | $ / shares                     $ 550.00 $ 520.00                    
Proceeds from sale of common stock, net | $                     $ 800,000 $ 8,700,000                    
Closing of offering date                       Apr. 17, 2017                    
Number of days granted as option to purchase additional shares of common stock to underwriter                       45 days                    
Additional shares of common stock                       1,888                    
Minimum [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Unrestricted cash and cash equivalents | $                         $ 2,000,000 $ 2,000,000   $ 2,000,000 $ 2,000,000 $ 2,000,000        
Maximum [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Unrestricted gross cash proceeds required to extend interest-only period | $                                   $ 7,500,000        
Maximum [Member] | Common Stock [Member] | B. Riley FBR [Member] | Sales Agreement [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Proceeds from sale of common stock, net | $             $ 6,500,000                              
2014 Equity Incentive Plan [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Number of shares callable by warrants (in shares)               9,100,000                       900,000    
Subsequent Event [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Reverse stock split of common stock 0.02                                          
Common stock, par value (in dollars per share) | $ / shares $ 0.001                                          
Preferred stock, shares authorized (in shares) 5,000,000                                          
Common stock, reverse stock split, fractional shares issued 0                                          
Reverse stock split of common stock description Upon effectiveness, each 50 shares of issued and outstanding Common Stock were converted into one newly issued and outstanding share of Common Stock.                                          
Reverse Stock Split Effective Date For Trading Purposes Aug. 06, 2019                                          
Sale of UK Subsidiary and Certain Assets [Member] | Loan and Security Agreement [Member] | Subsequent Event [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Cash proceeds from sale of subsidiary | $     $ 4,000,000                                      
Payments for principal, interest and fees | $     $ 1,700,000                                      
Sale of the Japanese Subsidiary and Certain Assets [Member] | Loan and Security Agreement [Member] | Subsequent Event [Member]                                            
Basis Of Presentation And New Accounting Standards [Line Items]                                            
Cash proceeds from sale of subsidiary | $   $ 3,000,000                                        
Payments for principal, interest and fees | $   $ 1,400,000