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Stock-based Compensation - Stock Option Activity (Details)
 12 Months Ended
Dec. 31, 2018
$ / shares
shares
Options [Roll Forward]  
Balance as of January 1, 2018 (in shares) | shares 2,017
Granted (in shares) | shares 2,346
Expired (in shares) | shares (20)
Cancelled/forfeited (in shares) | shares (1,591)
Balance as of December 31, 2018 (in shares) | shares 2,752
Weighted Average Exercise Price [Roll Forward]  
Balance as of January 1, 2018 (in dollars per share) | $ / shares $ 5,962.50
Granted (in dollars per share) | $ / shares 108.00
Expired (in dollars per share) | $ / shares 38,553.50
Cancelled/forfeited (in dollars per share) | $ / shares 296.50
Balance as of December 31, 2018 (in dollars per share) | $ / shares $ 4,003.50