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Organization and Operations - Additional Information (Details)
 1 Months Ended 3 Months Ended 12 Months Ended
Aug. 05, 2019
$ / shares
shares
Apr. 25, 2019
USD ($)
Apr. 24, 2019
USD ($)
Sep. 21, 2018
USD ($)
Aug. 28, 2018
$ / shares
Jul. 25, 2018
USD ($)
shares
Jun. 01, 2018
USD ($)
May 23, 2018
$ / shares
shares
Sep. 30, 2019
$ / shares
shares
Aug. 31, 2019
$ / shares
shares
Dec. 31, 2018
USD ($)
$ / shares
shares
Dec. 31, 2019
USD ($)
Subsidiary
$ / shares
shares
Dec. 31, 2018
USD ($)
$ / shares
shares
Aug. 16, 2019
shares
Aug. 06, 2019
shares
Jun. 30, 2019
USD ($)
May 24, 2018
shares
Dec. 31, 2017
USD ($)
shares
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Number of wholly-owned subsidiaries | Subsidiary                       5            
Proceeds from sale of business | $                       $ 5,637,000 $ 0          
Reverse stock split of common stock 0.02             0.1                    
Common stock, par value (in dollars per share) | $ / shares $ 0.001             $ 0.001     $ 0.001 $ 0.001 $ 0.001          
Common stock, shares authorized (in shares)               75,000,000     100,000,000 100,000,000 100,000,000       100,000,000  
Common stock, shares issued (in shares)               61,600,000     296,609 3,880,588 296,609       6,200,000  
Common stock, shares outstanding (in shares)               61,600,000     296,609 3,880,588 296,609       6,200,000  
Number of shares callable by warrants (in shares)               23,400,000                 2,300,000  
Preferred stock, shares authorized (in shares) 5,000,000             5,000,000     5,000,000 5,000,000 5,000,000   5,000,000   5,000,000  
Common stock, reverse stock split, fractional shares issued 0             0                    
Reverse stock split effective date for trading purposes Aug. 06, 2019                                  
Reverse stock split of common stock description                       Upon effectiveness, each 50 shares of issued and outstanding common stock were converted into one newly issued and outstanding share of common stock.            
Net loss | $                       $ 10,887,000 $ 12,634,000          
Accumulated deficit | $                     $ (414,383,000) (425,270,000) (414,383,000)          
Net cash used in operating activities | $                       $ (5,906,000) (11,975,000)          
Substantial doubt about going concern, description                       These factors raise substantial doubt about the Company’s ability to continue as a going concern            
Reimbursement revenue recognized | $                       $ 4,600,000            
Option vesting period                       4 years            
Option granted                       2,800            
Common stock issued, value | $                       $ 2,208,000 1,624,000          
Proceeds from sale of common stock, net | $                       15,964,000 0          
Proceeds from issuance warrants | $           $ 5,700,000                        
Stockholders' equity (deficit) | $                     $ 5,225,000 $ 1,160,000 $ 5,225,000         $ 13,000,000
Nasdaq Stock Market LLC [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Reverse stock split of common stock                   0.02                
Number of consecutive business days no longer able to meet the required closing bid price of common stock         30 days                          
Minimum bid price of common stock required for Nasdaq listing rule | $ / shares         $ 1.00         $ 1.00                
Grace period provided with minimum bid price for Nasdaq listing rule         180 days                          
Grace date for minimum bid price requirement for Nasdaq listing         Feb. 25, 2019                          
Common stock minimum bid price required to regain compliance | $ / shares         $ 1.00                          
Number of consecutive business days required to regain compliance         10 days                          
Date to regain compliance after meeting continued listing requirement         Aug. 26, 2019                          
Additional grace period provided with minimum bid price to regain compliance         180 days                          
Description of compliance with minimum bid price requirement                       The Company was granted an additional compliance period of 180 calendar days, or until August 26, 2019, in which to regain compliance after meeting the continued listing requirement for market value of publicly held shares and all other initial listing standards for the Nasdaq Capital Market, with the exception of the bid price requirement, and providing notice to Nasdaq staff of our intent to cure the deficiency during this second compliance period, by effecting a reverse stock split, if necessary.            
Shares, Outstanding                   786,807                
Stockholders' equity (deficit) | $                       $ (1,200,000)       $ 6,300,000    
Minimum stockholders equity requirement | $                       $ 2,500,000            
Minimum shares requirement for continued listing                           500,000        
Series U Warrants [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Common stock issued (in shares)                       3,450,000            
Sale of Stock, Price Per Share | $ / shares                       $ 5.00            
Representative Warrants [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Number of shares callable by warrants (in shares)                       75,000            
Warrant exercise price (in dollars per share) | $ / shares                       $ 6.25            
Common Stock [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Common stock, shares outstanding (in shares)                     296,609 3,880,588 296,609         115,651
Common stock issued (in shares)           6,723           184,666 92,169          
Warrant exercised                       65,114            
Stockholders' equity (deficit) | $                       $ 4,000            
Common Stock [Member] | Lincoln Park [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Common stock issued (in shares)                     12,802 32,170            
Common stock issued, value | $       $ 5,000,000                            
Period exercisable from the date of issuance       24 months                            
Proceeds from sale of common stock, net | $                     $ 300,000 $ 300,000            
Common Stock [Member] | B. Riley FBR [Member] | Sales Agreement [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Remaining availability under financing facility | $             $ 0                      
Common Stock [Member] | Maximum [Member] | B. Riley FBR [Member] | Sales Agreement [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Proceeds from sale of common stock, net | $             $ 6,500,000                      
Common Class A [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Common stock issued (in shares)                       289,000            
Common Class B [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Number of shares callable by warrants (in shares)                       2,711,000            
Series C Convertible Preferred Stock [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Preferred stock, shares authorized (in shares)           7,000                        
Common stock issued (in shares)           6,723                        
Common stock issued, value | $                         $ 3,041,000          
Underwriter [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Underwritten public offering description                 pursuant to which the Company sold in an underwritten public offering an aggregate of (i) 289,000 Class A Units, each consisting of one share of common stock, par value $0.001 per share, of the Company and one Series U warrant to purchase one share of common stock, and (ii) 2,711,000 Class B Units, each consisting of one pre-funded Series V warrant to purchase one share of common stock and one Series U Warrant to purchase one share of common stock at a public offering price of $5.00 per Class A Unit and $4.9999 per Class B Unit (“September 2019 Offering”). In addition, the Company granted the Underwriters a 45-day option to purchase up to an additional 450,000 shares of the Company’s common stock and/or Series U Warrants at the public offering price, less the underwriting discounts and commissions. The Underwriters exercised their option to purchase an additional 450,000 Series U warrants. The Company also issued to the Representative warrants (in the form of the Series U warrants) to purchase 75,000 shares of common stock with an exercise price of $6.25 per share of common stock (“Representative Warrants”).                  
Option vesting period                 45 days                  
Warrant granted                 450,000                  
Underwriter [Member] | Maximum [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Option granted                 450,000                  
Underwriter [Member] | Series U Warrants [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Warrant exercised                 450,000                  
Underwriter [Member] | Representative Warrants [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Number of shares callable by warrants (in shares)                 75,000                  
Warrant exercise price (in dollars per share) | $ / shares                 $ 6.25                  
Underwriter [Member] | Common Class A [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Common stock, par value (in dollars per share) | $ / shares                 $ 0.001                  
Common stock issued (in shares)                 289,000                  
Underwriter [Member] | Common Class A [Member] | Series U Warrants [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Sale of Stock, Price Per Share | $ / shares                 $ 5.00                  
Underwriter [Member] | Common Class B [Member] | Series V Warrants                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Number of shares callable by warrants (in shares)                 2,711,000                  
Underwriter [Member] | Common Class B [Member] | Series U Warrants [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Sale of Stock, Price Per Share | $ / shares                 $ 4.9999                  
2014 Equity Incentive Plan [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Number of shares callable by warrants (in shares)               9,100,000                 900,000  
Sale of UK Subsidiary and Certain Assets [Member] | Loan and Security Agreement [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Proceeds from sale of business | $     $ 4,000,000                              
Payments for principal, interest and fees | $     1,700,000                              
Sale of the Japanese Subsidiary and Certain Assets [Member] | Loan and Security Agreement [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Proceeds from sale of business | $   $ 3,000,000                                
Payments for principal, interest and fees | $   1,400,000                                
UK Subsidiary and Cell Therapy Assets [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Proceeds from sale of business | $     3,300,000                              
UK Subsidiary and Cell Therapy Assets [Member] | Amendment To Loan And Security Agreement                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Payments for principal, interest and fees | $     $ 1,700,000                              
Japanese Subsidiary and Cell Therapy Assets [Member]                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Proceeds from sale of business | $   2,400,000                                
Japanese Subsidiary and Cell Therapy Assets [Member] | Amendment To Loan And Security Agreement                                    
Basis Of Presentation And New Accounting Standards [Line Items]                                    
Payments for principal, interest and fees | $   $ 1,400,000