<SEC-DOCUMENT>0000899243-20-000160.txt : 20200102
<SEC-HEADER>0000899243-20-000160.hdr.sgml : 20200102
<ACCEPTANCE-DATETIME>20200102204734
ACCESSION NUMBER:		0000899243-20-000160
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20200101
FILED AS OF DATE:		20200102
DATE AS OF CHANGE:		20200102

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			van Es-Johansson An
		CENTRAL INDEX KEY:			0001795902

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34375
		FILM NUMBER:		20503065

	MAIL ADDRESS:	
		STREET 1:		6863 BEE CAVE ROAD
		STREET 2:		SUITE 200
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78736

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PLUS THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001095981
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				330827593
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		4200 MARATHON BLVD.
		STREET 2:		SUITE 200
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78756
		BUSINESS PHONE:		737.255.7194

	MAIL ADDRESS:	
		STREET 1:		4200 MARATHON BLVD.
		STREET 2:		SUITE 200
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78756

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CYTORI THERAPEUTICS, INC.
		DATE OF NAME CHANGE:	20050712

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MACROPORE INC
		DATE OF NAME CHANGE:	20010320
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<TYPE>3
<SEQUENCE>1
<FILENAME>doc3.xml
<DESCRIPTION>FORM 3 SUBMISSION
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<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2020-01-01</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001095981</issuerCik>
        <issuerName>PLUS THERAPEUTICS, INC.</issuerName>
        <issuerTradingSymbol>PSTV</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001795902</rptOwnerCik>
            <rptOwnerName>van Es-Johansson An</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O PLUS THERAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>4200 MARATHON BOULEVARD, SUITE 200</rptOwnerStreet2>
            <rptOwnerCity>AUSTIN</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>78756</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks>Exhibit List: Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ An van Es-Johansson</signatureName>
        <signatureDate>2020-01-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>attachment1.htm
<DESCRIPTION>EX-24 DOCUMENT
<TEXT>
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<PRE>
                                                                      Exhibit 24

                               POWER OF ATTORNEY

        For Executing Section 16 Forms, Form 144 and Schedule 13D or 13G


           Know all by these present that the undersigned hereby constitutes
and appoints Marc H. Hedrick and Desiree Smith, or any of them signing
individually, the undersigned's true and lawful attorney-in-fact to:

(1)        execute for and on behalf of the undersigned, in the undersigned's
           capacity as an officer and/or director of Plus Therapeutics, Inc.
           (the "Company") (a) Forms 3, 4 and 5 (including amendments thereto)
           in accordance with Section 16(a) of the Securities Exchange Act of
           1934 and the rules thereunder, (b) Form 144, and (c) Schedule 13D or
           Schedule 13G; and

(2)        do and perform any and all acts for and on behalf of the undersigned
           that may be necessary or desirable to complete and execute any such
           Forms 3, 4 and 5, Form 144, and Schedule 13D or Schedule 13G
           (including amendments thereto) and timely file such Forms or
           schedules with the SEC and any stock exchange, self-regulatory
           association or any other authority; and

(3)        take any other action of any type whatsoever in connection with the
           foregoing that, in the opinion of such attorney-in-fact, may be of
           benefit to, in the best interest of, or legally required of the
           undersigned, it being understood that the documents executed by the
           attorney-in-fact on behalf of the undersigned pursuant to this Power
           of Attorney shall be in such form and shall contain such terms and
           conditions as the attorney-in-fact may approve in the attorney-in-
           fact's discretion.

           The undersigned hereby grants to the attorney-in-fact full power and
authority to do and perform all and every act and thing whatsoever requisite,
necessary or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could do if personally present, with full power of substitution or revocation,
hereby ratifying and confirming all that the attorney-in-fact shall lawfully do
or cause to be done by virtue of this Power of Attorney and the rights and
powers herein granted.  The undersigned acknowledges that the foregoing
attorney-in-fact, in serving in such capacity at the request of the undersigned,
is not assuming any of the undersigned's responsibilities to comply with Section
16 of the Securities Exchange Act of 1934.

           The undersigned agrees that such attorney-in-fact may rely entirely
on information furnished orally or in writing by the undersigned to the
attorney-in-fact.  The undersigned also agrees to indemnify and hold harmless
such attorney-in- fact against any losses, claims, damages or liabilities (or
actions in these respects) that arise out of or are based upon any untrue
statements or omissions of necessary facts in the information provided by the
undersigned to such attorney-in fact for purposes of executing, acknowledging,
delivering or filing Form 4 or Form 144 (including amendments thereto) and
agrees to reimburse the attorney-in-fact on demand for any legal or other
expenses reasonably incurred in connection with investigating or defending
against any such loss, claim, damage, liability or action.

           This Power of Attorney shall remain in full force and effect until
the undersigned is no longer required to file Forms 3, 4 and 5 with respect to
the undersigned's holdings of and transactions in securities issued by the
Company, unless earlier revoked by the undersigned in a signed writing delivered
to the foregoing attorney-in-fact.

           IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
to be executed as of the date written below.



Signature: /s/ An van Es-Johansson
           --------------------
Printed Name: An van Es-Johansson
              --------------------
Date: 1/2/2020

</PRE>
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