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Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2020

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Stock Option Activity

          A summary of activity for the year ended December 31, 2020 is as follows:

		Options				Weighted Average Exercise Price
Balance as of December 31, 2019			1,865			$	2,968.22
Granted			530,000			$	2.12
Cancelled/forfeited			(529	)		$	2,486.82
Balance as of December 31, 2020			531,336			$	10.01

Stock Options Vested and Expected to Vest

		Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (years)				Aggregate Intrinsic Value
Balance as of December 31, 2020			531,336			$	10.01				9.41			$	-
Vested and expected to vest at December 31, 2020			490,008			$	10.52				9.41			$	-
Exercisable at December 31, 2020			75,028			$	56.84				9.43			$	-

Weighted-average Assumptions

The fair value of each option awarded during the years ended December 31, 2020 and 2019 was estimated on the date of grant using the Black-Scholes-Merton option valuation model based on the following weighted-average assumptions:

		December 31, 2020				December 31, 2019
Expected term		5.8 years				7.0 years
Risk-free interest rate			0.58	%			2.41	%
Expected volatility			128.6	%			96.5	%
Dividends			0	%			0	%
Resulting fair value		$	1.87			$	0.26

Summary of Share-Based Compensation Recognized

The following table summarizes share-based compensation recognized during the years ended December 31, 2020 and 2019 in the statement of operations and comprehensive loss:

		Years ended December 31,
		2020				2019
Research and development		$	32			$	40
General and administrative			215				87
Total share-based compensation		$	247			$	127

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Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

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-Name Accounting Standards Codification
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Tabular disclosure of activity for award under share-based payment arrangement. Includes, but is not limited to, outstanding award at beginning and end of year, granted, exercised, forfeited, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Tabular disclosure of number, weighted-average exercise price or conversion ratio, aggregate intrinsic value, and weighted-average remaining contractual term for outstanding and exercisable options that are fully vested and expected to vest. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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