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Stockholders' Equity - Preferred Stock (Details) - $ / shares
 1 Months Ended 12 Months Ended
Apr. 30, 2020
Sep. 30, 2019
Dec. 31, 2020
Dec. 31, 2019
Preferred Stock [Abstract]        
Preferred stock, shares authorized (in shares)     5,000,000 5,000,000
Preferred stock, par value (in dollars per share)     $ 0.001 $ 0.001
Preferred stock, shares outstanding (in shares)     1,954 1,959
Series A Convertible Preferred Stock [Member]        
Preferred Stock [Abstract]        
Preferred stock, shares outstanding (in shares)     0 0
Convertible preferred stock     3.60% 3.60%
Series B Convertible Preferred Stock [Member]        
Preferred Stock [Abstract]        
Preferred stock, shares outstanding (in shares)     1,016 1,021
Series B Convertible Preferred Stock [Member] | 2018 Rights Offering [Member]        
Preferred Stock [Abstract]        
Preferred stock, shares outstanding (in shares)     1,016  
Number of preferred stock, shares converted     6,096  
Series C Convertible Preferred Stock [Member]        
Preferred Stock [Abstract]        
Preferred stock, shares outstanding (in shares)     938 938
Conversion Price Per Share $ 3.2132 $ 3.2132   $ 39.93
Preferred stock conversion price reduced (in dollars per share) $ 2.25 $ 7.50   $ 7.50
Series C Convertible Preferred Stock [Member] | 2018 Rights Offering [Member]        
Preferred Stock [Abstract]        
Preferred stock, shares outstanding (in shares)     938  
Number of preferred stock, shares converted     416,889