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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows used in operating activities: |  |
Net loss | $ (13,399) | $ (8,241)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 395 | 366
Amortization of deferred financing costs and debt discount | 546 | 584
In process research and development acquired | 250 | 781
Change in fair value of liability instruments | (6) | (2,400)
Loss on disposal of property and equipment | 66 | 0
Share-based compensation expense | 606 | 247
Inventory write off | 0 | 107
Non-cash lease expense | 24 | 3
Increases (decreases) in cash caused by changes in operating assets and liabilities: |  |
Accounts receivable | 0 | 1,169
Other current assets | (496) | 126
Other assets | 0 | 58
Accounts payable and accrued expenses | 1,734 | (1,234)
Other long-term liabilities | 0 | 0
Net cash used in operating activities | (10,280) | (8,434)
Cash flows from (used in) investing activities: |  |
Purchases of property and equipment and intangible assets | (144) | (93)
Proceeds from sale of property and equipment | 62 | 0
In process research and development acquired from NanoTx Therapeutics | 0 | (400)
Net cash used in investing activities | (82) | (493)
Cash flows from financing activities: |  |
Principal payments of long-term obligations | (268) | (5,307)
Payment of financing lease liability | (8) | (117)
Proceeds from exercise of warrants | 2,017 | 1,098
Proceeds from sale of common stock | 18,675 | 4,007
Net cash provided by (used in) financing activities | 20,416 | (319)
Net increase (decrease) in cash and cash equivalents | 10,054 | (9,246)
Cash and cash equivalents at beginning of period | 8,346 | 17,592
Cash and cash equivalents at end of period | 18,400 | 8,346
Cash paid during period for: |  |
Interest | 388 | 567
Supplemental schedule of non-cash investing and financing activities: |  |
Unpaid offering cost | 219 | 125
Issuance costs paid in common stock | 0 | 463
Common stock issued in payment for in process research and development | 0 | 381
Reclassification of warrants liability to equity | $ 0 | $ 4,504

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