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Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2021
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] |
Stock Option Activity | A summary of activity for the year ended December 31, 2021 is as follows:
|  | Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term (years) |  |  | Aggregate Intrinsic Value |
Balance as of December 31, 2020 |  |  | 531,336 |  |  | $ | 10.01 |  |  |  |  |  |  |  |  |
Granted |  |  | 680,227 |  |  | $ | 2.52 |  |  |  |  |  |  |  |  |
Cancelled/forfeited |  |  | (40,673 | ) |  | $ | 16.69 |  |  |  |  |  |  |  |  |
Balance as of December 31, 2021 |  |  | 1,170,890 |  |  | $ | 5.01 |  |  |  | 9.00 |  |  | $ | - |
Vested and expected to vest at December 31, 2021 |  |  | 378,010 |  |  | $ | 10.37 |  |  |  | 8.70 |  |  | $ | - |
Exercisable at December 31, 2021 |  |  | 1,089,944 |  |  | $ | 5.16 |  |  |  | 9.00 |  |  | $ | - |
Weighted-average Assumptions | The fair value of each option awarded during the years ended December 31, 2021 and 2020 was estimated on the date of grant using the Black-Scholes-Merton option valuation model based on the following weighted-average assumptions:
|  | December 31, 2021 |  |  | December 31, 2020 |
Expected term |  |  | 6 years |  |  | 5.8 years |
Risk-free interest rate |  |  | 1.00 | % |  |  | 0.58 | %
Expected volatility |  |  | 127.0 | % |  |  | 128.6 | %
Dividends |  |  | 0 | % |  |  | 0 | %
Resulting fair value |  | $ | 2.23 |  |  | $ | 1.87 |
Summary of Share-Based Compensation Recognized | The following table summarizes share-based compensation recognized during the years ended December 31, 2021 and 2020 in the statement of operations and comprehensive loss:
|  | Years ended December 31, |
|  | 2021 |  |  | 2020 |
Research and development |  | $ | 75 |  |  | $ | 32 |
General and administrative |  |  | 531 |  |  |  | 215 |
Total share-based compensation |  | $ | 606 |  |  | $ | 247 |

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- Definition Tabular disclosure of activity for award under share-based payment arrangement. Includes, but is not limited to, outstanding award at beginning and end of year, granted, exercised, forfeited, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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