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Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2021

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Stock Option Activity

          A summary of activity for the year ended December 31, 2021 is as follows:

		Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (years)				Aggregate Intrinsic Value
Balance as of December 31, 2020			531,336			$	10.01
Granted			680,227			$	2.52
Cancelled/forfeited			(40,673	)		$	16.69
Balance as of December 31, 2021			1,170,890			$	5.01				9.00			$	-
Vested and expected to vest at December 31, 2021			378,010			$	10.37				8.70			$	-
Exercisable at December 31, 2021			1,089,944			$	5.16				9.00			$	-

Weighted-average Assumptions

The fair value of each option awarded during the years ended December 31, 2021 and 2020 was estimated on the date of grant using the Black-Scholes-Merton option valuation model based on the following weighted-average assumptions:

		December 31, 2021				December 31, 2020
Expected term			6 years			5.8 years
Risk-free interest rate			1.00	%			0.58	%
Expected volatility			127.0	%			128.6	%
Dividends			0	%			0	%
Resulting fair value		$	2.23			$	1.87

Summary of Share-Based Compensation Recognized

The following table summarizes share-based compensation recognized during the years ended December 31, 2021 and 2020 in the statement of operations and comprehensive loss:

		Years ended December 31,
		2021				2020
Research and development		$	75			$	32
General and administrative			531				215
Total share-based compensation		$	606			$	247

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Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

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-Name Accounting Standards Codification
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Tabular disclosure of activity for award under share-based payment arrangement. Includes, but is not limited to, outstanding award at beginning and end of year, granted, exercised, forfeited, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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