    <SEC-DOCUMENT>0001564590-22-013877-index.html : 20220407
    <SEC-HEADER>0001564590-22-013877.hdr.sgml : 20220407
    <ACCEPTANCE-DATETIME>20220407170056
    ACCESSION NUMBER:		0001564590-22-013877
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		7
    CONFORMED PERIOD OF REPORT:	20220516
    FILED AS OF DATE:		20220407
    DATE AS OF CHANGE:		20220407

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			PLUS THERAPEUTICS, INC.
    		CENTRAL INDEX KEY:			0001095981
    		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
    		IRS NUMBER:				330827593
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-34375
    		FILM NUMBER:		22814546

    	BUSINESS ADDRESS:
    		STREET 1:		4200 MARATHON BLVD.
    		STREET 2:		SUITE 200
    		CITY:			AUSTIN
    		STATE:			TX
    		ZIP:			78756
    		BUSINESS PHONE:		737.255.7194

    	MAIL ADDRESS:
    		STREET 1:		4200 MARATHON BLVD.
    		STREET 2:		SUITE 200
    		CITY:			AUSTIN
    		STATE:			TX
    		ZIP:			78756

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	CYTORI THERAPEUTICS, INC.
    		DATE OF NAME CHANGE:	20050712

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	MACROPORE INC
    		DATE OF NAME CHANGE:	20010320
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>pstv-def14a_20220516.htm
    <DESCRIPTION>DEF 14A
    <TEXT>
    Document 1 - file: pstv-def14a_20220516.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>gdtdc5zscevp000005.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: gdtdc5zscevp000005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>gdtdc5zscevp000002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: gdtdc5zscevp000002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>gdtdc5zscevp000006.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: gdtdc5zscevp000006.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>gdtdc5zscevp000001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: gdtdc5zscevp000001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>gdtdc5zscevp000004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: gdtdc5zscevp000004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>gdtdc5zscevp000007.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: gdtdc5zscevp000007.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>