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Document and Entity Information
Mar. 31, 2022
Cover [Abstract]  
Document Type 8-K
Amendment Flag false
Document Period End Date Mar. 31, 2022
Entity Registrant Name PLUS THERAPEUTICS, INC.
Entity Central Index Key 0001095981
Entity Emerging Growth Company false
Entity File Number 001-34375
Entity Incorporation State Country Code DE
Entity Tax Identification Number 33-0827593
Entity Address, Address Line One 4200 Marathon Blvd.
Entity Address, Address Line Two Suite 200
Entity Address, City or Town Austin
Entity Address, State or Province TX
Entity Address, Postal Zip Code 78756
City Area Code 737
Local Phone Number 255-7194
Written Communications false
Soliciting Material false
Pre Commencement Tender Offer false
Pre Commencement Issuer Tender Offer false
Security 12b Title Common Stock, par value $0.001 per share
Trading Symbol PSTV
Security Exchange Name NASDAQ