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Document and Entity Information
 3 Months Ended
Mar. 31, 2024
Cover [Abstract]  
Entity Registrant Name PLUS THERAPEUTICS, INC.
Entity Central Index Key 0001095981
Current Fiscal Year End Date --12-31
Entity Filer Category Non-accelerated Filer
Entity Emerging Growth Company false
Entity Small Business true
Document Fiscal Year Focus 2024
Document Fiscal Period Focus Q1
Document Type 10-Q
Amendment Flag false
Document Period End Date Mar. 31, 2024
Document Quarterly Report true
Document Transition Report false
Entity Interactive Data Current Yes
Entity Current Reporting Status Yes
Entity Shell Company false
Trading Symbol PSTV
Title of 12(b) Security Common Stock, par value $0.001
Security Exchange Name NASDAQ
Entity File Number 001-34375
Entity Incorporation, State or Country Code DE
Entity Tax Identification Number 33-0827593
Entity Address, Address Line One 4200 MARATHON BLVD
Entity Address, Address Line Two SUITE 200
Entity Address, City or Town AUSTIN
Entity Address, State or Province TX
Entity Address, Postal Zip Code 78756
City Area Code 737
Local Phone Number 255-7194