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Cover Page
 3 Months Ended
Mar. 31, 2024
Document Information [Line Items]  
Document Type S-1
Amendment Flag false
Entity Registrant Name PLUS THERAPEUTICS, INC.
Entity Central Index Key 0001095981
Entity Filer Category Non-accelerated Filer
Entity Small Business true
Entity Emerging Growth Company false
Entity Incorporation, State or Country Code DE
Entity Tax Identification Number 33-0827593
Entity Address, Address Line One 4200 Marathon Blvd.
Entity Address, Address Line Two Suite 200
Entity Address, City or Town Austin
Entity Address, State or Province TX
Entity Address, Postal Zip Code 78756
City Area Code 737
Local Phone Number 255-7194
Entity Primary SIC Number 2834
Business Contact [Member]  
Document Information [Line Items]  
Entity Address, Address Line One 4200 Marathon Blvd.
Entity Address, Address Line Two Suite 200
Entity Address, City or Town Austin
Entity Address, State or Province TX
Entity Address, Postal Zip Code 78756
City Area Code 737
Local Phone Number 255-7194
Contact Personnel Name Marc H. Hedrick, M.D.